ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (3): 246-249.doi: 10.3969/j.issn.1674-3865.2017.03.020

• 临床研究 • 上一篇    下一篇

高压氧结合药物综合治疗小儿病毒性脑炎临床疗效观察

胡文静，方红军，王平，杨赛，冯枚   

  1. 410007 长沙，湖南省儿童医院神经二科
  • 出版日期:2017-06-25 发布日期:2017-12-08
  • 通讯作者: 胡文静，E-mail:sunxianyou@126.com
  • 作者简介:胡文静（1985-），女，医学硕士，主治医师。研究方向：儿童神经系统疾病的诊治

Clinical efficacy of the treatment with hyperbaric oxygen combined with drugs  for viral encephalitis in children

HU Wenjing，FANG Hongjun，WANG Ping，YANG Sai，FENG Mei   

  1. Department of Neurology, Children 's Hospital of Hunan Province，Changsha 410007，China
  • Online:2017-06-25 Published:2017-12-08

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摘要：
目的
研究高压氧结合药物综合治疗小儿病毒性脑炎的临床疗效及实验室指标的变化情况。
方法
选择2011年3月至2016年3月在湖南省儿童医院就诊的病毒性脑炎患儿153例作为研究对象，随机分为观察组77例和对照组76例。对照组患儿给予抗病毒、退热、镇静、止吐、营养支持等药物综合对症治疗；观察组患儿在对照组治疗的基础上结合高压氧治疗，每日1次，连续治疗7 d为1个疗程。连续进行3个疗程后，对两组患儿的临床疗效及实验室指标的比较，如患儿血管内皮生长因子、可溶性血管细胞黏附因子1、β内啡肽以及髓鞘碱性蛋白的检测结果比较等。
结果
观察组的临床总有效率为94.81%（73/77），显著高于对照组82.89%（63/76），差异有统计学意义（P<0.05）。观察组患儿经治疗后其血管内皮生长因子、可溶性血管细胞黏附因子1、β内啡肽和髓鞘碱性蛋白的检测值与观察组治疗前、对照组治疗后先比显著降低，差异有统计学意义（P<0.05）。
结论
高压氧结合药物综合治疗小儿病毒性脑炎较单纯药物对症治疗具有更好的临床治疗效果，更利于患儿病情的恢复，该治疗方案值得在临床上推广和应用。

关键词: 脑炎, 病毒性, 高压氧治疗, 疗效, 儿童

Abstract:
Objective
To investigate the clinical efficacy of hyperbaric oxygen combined with drugs and changes of laboratory-related indicators in children with viral encephalitis.
Methods
Fifty-five children with viral encephalitis treated in our hospital from March 2011 to March 2016 were selected as the clinical subjects. They were randomly divided into two groups: the observation group of 77 cases and the control group of 76 cases. The patients in the control group were treated with anti-virus, anti-fever, sedation and antiemetic treatment and nutritional support; the patients in the observation group were treated with hyperbaric oxygen therapy in addition to the treatment for the control group, once a day for 7 days as a course of treatment. After three consecutive courses, the clinical efficacy and laboratory parameters of the two groups  were compared, such as vascular endothelial growth factor(VEGF), soluble vascular cell adhesion factor 1(sVCAM-1), β-endorphin(β-EP) and myelin basic protein(MBP).
Results
The total effective rate was 94.81%(73/77) in the observation group, which was significantly higher than that in the control group(82.89%, 63/76), the difference being statistically significant(P<0.05). After treatment, vascular endothelial growth factor(VEGF), soluble vascular cell adhesion molecule 1(sVCAM-1), β-endorphin(β-EP) and myelin basic protein(MBP) in the observation group were significantly reduced, and compared with the observation group before treatment and the control group after treatment, the difference was statistically significant(P<0.05).
Conclusion
Hyperbaric oxygen combined with drug treatment for children with viral encephalitis is more effective than the simple drug symptomatic treatment, which is more favorable for the recovery of the children.

 

Key words: Encephalitis, Viral, Hyperbaric oxygen therapy, Efficacy, Children