关键词: 肺炎链球菌病, 重症监护病房, 临床特点, 儿童

Abstract:
Objective
To analyze the clinical characteristics of invasive pneumonia Streptococcosis in children in intensive care unit(ICU) and observe its prognosis.
Methods
From February 2016 to February 2018, 60 children with invasive pneumococcal Streptococcosis were treated in intensive care unit of Hunan Children's Hospital, including 30 cases of bacterial meningitis, 20 cases of bacterial pleurisy, 8 cases of sepsis and 2 cases of necrotizing fasciitis. The clinical characteristics and prognosis of invasive pneumonia Streptococcosis were retrospectively analyzed. Blood, pleural effusion and cerebrospinal fluid samples were collected for bacterial isolation, culture and drug sensitivity test, and antibiotics were used for treatment.
Results
The incidence of Haemophilus syndrome was 8.33%(5 children), septic shock was found in 4 children, the incidence being 6.67%, and acute respiratory distress syndrome was found in 8 children, the incidence being 13.33%. The coverage rate of Streptococcus pneumoniae conjugate vaccine reached 97.6%. Only one strain of Streptococcus pneumoniae showed significant resistance to all antibiotics tested. Among them, antibiotic-insensitive Streptococcus pneumoniae accounted for 76.3%, and penicillin-resistant Streptococcus pneumoniae accounted for 54.8%. A total of 50 children survived, with a survival rate of 83.33%. Of the 8 children with sepsis, 4 were complicated with septic shock, and 3 died; 4 without septic shock survived. In addition, 2 of 5 children with hemophilia syndrome died and all the 5 children with respiratory distress syndrome died.
ConclusionThe clinical characteristics of children with invasive pneumonia Streptococcosis in intensive care unit are remarkable. Targeted antibiotic therapy based on pathogenic bacteria can reduce the incidence of prognostic complications.

Key words: Streptococcus pneumoniae, Intensive care unit, Clinical characteristics, Children