ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (6): 502-506.doi: 10.3969/j.issn.1674-3865.2018.06.014

• 临床研究 • 上一篇    下一篇

中药治疗儿童咳嗽变异性哮喘随机对照临床文献的Meta分析

司振阳   

  1. 210001 南京，南京市中医院儿科
  • 出版日期:2018-12-25 发布日期:2019-03-25
  • 作者简介:司振阳(1982-)，男，主治医师。研究方向：儿童肺系疾病的诊治，E-mail：njszyyek@163.com
  • 基金资助:
    江苏省中医药管理局资助项目(LZ13100)；“十三五”南京市卫生青年人才培养工程(NWQR201712)；南京市张骠名中医工作室项目资助

Meta-analysis of pure traditional Chinese medicine in treating cough variant asthma in children

SI Zhenyang   

  1. Pediatric Department，Nanjing TCM Hospital，Nanjing 210001,China
  • Online:2018-12-25 Published:2019-03-25

PDF (PC)

87

摘要：
目的
系统评价单纯中药治疗儿童咳嗽变异性哮喘(CVA)的临床疗效和安全性。
方法
计算机检索考克兰图书馆、PUBMED、EMBASE数据库、中国期刊全文数据库、中国生物医学文献数据库，中国科技期刊全文数据库以及中国万方数据库等数据库，检索的时间范围是自每个数据库建库到2017年11月，纳入所有单纯中药治疗儿童CVA的随机对照试验。由两位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后，采用RevMan 53软件进行Meta分析。
结果
最终纳入34个研究，共2 230例患者。Meta分析结果显示，与单纯使用西药相比，中药能显著提高儿童CVA的临床有效率［RR=1.20，95%CI(1.12，1.29)，P<0.000 01］；降低复发率［RR=0.40，95%CI(0.21,0.77)，P=0.005］；减少不良反应发生率［RR=0.07，95%CI(0.04，0.13)，P<0.000 01］，其差异均具有统计学意义。
结论
基于当前的临床证据，本研究结果显示中药在临床有效性和安全性方面较单纯西药治疗有一定的优势。

关键词: 咳嗽变异性哮喘, 中药, 随机对照试验, Meta分析, 儿童

Abstract:
Objective
To systematically evaluate the therapeutic effect and safety of traditional Chinese medicine in the treatment of children with cough variant asthma．
Methods
We searched The Cochrane Library，PubMed，Embase，CNKI，SinoMed，VIP and WanFang Databases to collect randomized controlled trials(RCTs) on traditional Chinese medicine in the treatment of cough variant asthma in children from inception to November 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies and made a Meta-analysis by using RevMan5.3 software．
Results
A total of 34 RCTs involving 2 230 patients were included into the study．The Meta-analysis results showed that compared with western medicine，the traditional Chinese medicine could significantly improve the clinical efficiency［RR=1.20，95%CI(1.12，1.29)，P＜0.000 01］，decrease the recurrence rate［RR=0.40，95%CI(0.21,0.77)，P=0.005］，and reduce the incidence of adverse reactions［RR=0.07，95%CI(0.04，0.13)，P＜0.000 01］，and there were statistically significant differences between the two groups．
ConclusionBased on the current evidence, this study shows that the traditional Chinese medicine is superior to western medicine in overall clinical efficacy and as the safety of  treatment.

Key words: Cough variant asthma, Traditional Chinese medicine, Randomized controlled trials, Meta-analysis, Child