ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (5): 410-413.doi: 10.3969/j.issn.1674-3865.2017.05.014

• 临床研究 • 上一篇    下一篇

仙方承气汤直肠滴入治疗重症手足口病脑炎疗效观察

杨璞叶，刘叶红，付青青，杨震   

  1. 710061西安，西安市第八医院中西医结合科（杨璞叶，付青青）|710043 西安，西安市北方医院感染科（刘叶红）|710018 西安，西安市中医医院（杨震）
  • 出版日期:2017-10-25 发布日期:2017-12-18
  • 通讯作者: 杨璞叶，E-mail：164866486@qq.com
  • 作者简介:杨璞叶（1969-），女，医学硕士，主任医师。研究方向：中西医结合治疗传染病
  • 基金资助:
    杨震全国名老中医药专家工作室建设项目（国家中医药人教发【2011】41号）

Clinical effect of Xianfang Chengqi decoction for rectal dripping in the treatment of severe hand-foot-mouth disease encephalitis

YANG Puye，LIU Yehong，FU Qingqing，YANG Zhen   

  1. Department of Integrated Traditional Chinese and Western Medicine, the Eighth Hospital of Xi'an, Xi'an 710061, China
  • Online:2017-10-25 Published:2017-12-18

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187

摘要：
目的
观察仙方承气汤治疗重症手足口病脑炎的临床疗效。
方法
2014年3月至2016年6月西安市北方医院感染科收治重症手足口病2期（神经系统受累期）患儿104例，随机分为观察组和对照组各52例。两组均给予抗病毒药物、退热补液对症支持治疗。对照组静脉滴注人免疫球蛋白治疗。观察组采用仙方承气汤直肠滴入治疗。治疗2 d观察两组临床疗效，两组胃肠功能障碍时间、发热持续时间、抖动、易惊时间、血压异常时间、心率异常时间、住院时间及不良反应。
结果
观察组显效率为86.6%（45/52），显著高于对照,42.35%(22/52)，差异有统计学意义(P<0.05)。观察组患儿胃肠功能障碍时间，发热持续时间，抖动、易惊时间，血压异常时间，心率异常时间，住院时间显著低于对照组，差异有统计学意义(P<0.05)。两组均未见明显不良反应。
结论
仙方承气汤直肠给药治疗重症手足口病脑炎可抑制、阻断病情，疗效显著、操作简单、安全。

关键词: 重症手足口病, 通腑泄热, 仙方承气汤, 儿童

Abstract:
Objective
To observe the clinical effect of Xianfang Chengqi decoction in the treatment of severe hand-foot-mouth disease(HFMD) encephalitis.
Methods
A total of 104 children with HFMD (phase Ⅱ,phase of neurological involvement) were included in the study ,who received treatment in Xi'an Northern Hospital from Mar. 2014 to June 2016,and they were randomly divided into two groups: observation group(n=52) and control group（n=52）.Both groups received symptomatic supportive treatment with antiviral medicine and abatement of fever and fluid infusion. The control group was also given intravenous drip of human immunoglobulin, and the observation group was given rectal dripping of Xianfang Chengqi decoction. After two days of treatment, the clinical effect of the two groups was observed, as well as the time period of gastrointestinal dysfunction, fever, shaking, skittishness, abnormal blood pressure and abnormal heart rate, and the length of hospital stay and adverse reactions.
Results
The effective rate of observation group was 86.6%（45/52）,significantly higher than that of control group(42.35%,22/52),the difference being statistical(P<0.05).The time period of fever, shaking, being skittish, abnormal blood pressure, abnormal heart rate and hospital stay in the observation group was significantly shorter than that in control group, and there was statistical difference (P<0.05). There were no obvious adverse reactions in both groups.
Conclusion
Xianfang Chenqi decoction for rectal dripping can inhibit and block the disease in the treatment of severe hand-foot-mouth disease encephalitis. It is significantly effective, safe and easy to operate.

Key words: Severe hand-foot-mouth disease, Purging organs to eliminate heat, Xianfang Chengqi decoction, Child