ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 333-339.doi: 10.3969/j.issn.1674-3865.2019.04.016

• 临床研究 • 上一篇    下一篇

复方中药治疗儿童抽动障碍随机对照试验的Meta分析

姜俊爽，王雪峰，张秀英，关卉婷   

  1. 110032 沈阳，辽宁中医药大学2017级中医儿科学专业研究生(姜俊爽)，2018级中医儿科学专业研究生(关卉婷)；辽宁中医药大学附属医院儿科(王雪峰，张秀英)
  • 出版日期:2019-08-25 发布日期:2019-09-18
  • 通讯作者: 王雪峰，E-mail：lnzywxf@163.com
  • 作者简介:姜俊爽(1993-)，女，辽宁中医药大学2017级硕士研究生在读。研究方向：中医药防治儿童神经精神疾病

A Meta-analysis of randomized controlled trials of compound Chinese medicine in the treatment of children with Tic disorders

JIANG Junshuang，WANG Xuefeng，ZHANG Xiuying，GUAN Huiting   

  1. Liaoning University of Traditional Chinese Medicine，Shenyang 110032， China
  • Online:2019-08-25 Published:2019-09-18

PDF (PC)

123

摘要：
目的
评价复方中药治疗儿童抽动障碍的疗效和安全性。
方法
计算机检索PubMed、CNKI、万方、维普等中英文数据库从2015年1月1日至2019年3月31日复方中药治疗儿童抽动障碍的随机对照试验文献，由两位研究员进行文献筛选，应用RevMan 5-3软件中ROB偏倚风险评估表对纳入文献的质量进行评估并进行Meta分析。
结果
最终共有29篇文献，2370例患儿纳入了本项研究。本次Meta分析结果显示，复方中药治疗儿童抽动障碍的总有效率高于西药组OR=2.23，95%CI(1.73，2.87)，P<0.000 01］，复方中药组的远期疗效(半年)高于西药组OR=4.92，95%CI(3.16，7.66)，P<0.000 01］，耶鲁评分方面两组比较差异无统计学意义，其中有20篇文献报告了不良反应。
结论
根据近四年半随机对照试验文献显示，复方中药在治疗抽动障碍方面有良好的临床效果，但因纳入研究的文献质量较低且存在发表偏倚等可能性，想要获得更加可靠、准确的评价，仍需要大样本、多中心的高质量随机对照试验研究以提供临床依据。

关键词: 抽动障碍, Meta分析, 中药, 儿童

Abstract:
Objective
To evaluate the efficacy and safety of compound Chinese medicine in the treatment of children with Tic disorders.
Methods
Randomized controlled trials of compound Chinese medicine in the treatment of children with Tic disorders from January 1，2015 to March 31，2019 were retrieved from PubMed, CNKI, Wanfang and Weipu databases by computer; two researchers screened the papers; ROB bias risk assessment form in RevMan 5.3 software was used to evaluate the quality of included papers and Meta-analysis was performed.
Results
A total of 29 papers containing 2 370 cases were included in the study. The Meta-analysis showed that the total effective rate of TCM group was higher than that of western medicine group in the treatment of children with Tic disorders［OR=2.23，95%CI(1.73，2.87)，P＜0.000 01］ and the long-term（half a year）efficacy of TCM group was higher than that of western medicine group［OR=4.92，95%CI(3.16，7.66)，P＜0.000 01］，but there was no significant difference in Yale score between the two groups; twenty of them reported side effects.
Conclusion
According to the studies of randomized controlled trials in the recent four and a half years， compound Chinese medicines have good clinical effects in the treatment of Tic disorders. However， due to the low quality of the papers included in the study and the possibility of publication bias，large sample, multicenter, high-quality randomized controlled trials are still needed to provide clinical basis in order to obtain more reliable and accurate evaluation.

Key words: Tic disorders, Meta-analysis, Chinese herbal medicine, Child