ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 589-591.doi: 10.3969/j.issn.1674-3865.2016.06.012

• 临床研究 • 上一篇    下一篇

布拉氏酵母菌治疗小儿急性腹泻及对细胞免疫功能的影响

赵进方，赵黎明   

  1. 457000 河南 濮阳，濮阳市妇幼保健院儿科
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 通讯作者: 赵进方，E-mail：puyangzjf@126.com
  • 作者简介:赵进方(1963-)，男，副主任医师。研究方向：小儿消化系统疾病的诊治

Clinical effect of saccharomyces boulardii sachets in the treatment of children with acute diarrhea and its impact on the cellular immune function

ZHAO Jinfang，ZHAO Liming   

  1. Puyang City Maternal And Child Health Care Hospital，Puyang 457000，China
  • Online:2016-12-25 Published:2018-11-19

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摘要： 目的：观察布拉氏酵母菌散治疗小儿急性腹泻的疗效及对细胞免疫功能的影响。
方法：2013年5月至2014年5月濮阳市妇幼保健院儿科收治住院的急性腹泻患儿88例，随机分为对照组与观察组各44例。对照组口服蒙脱石散，观察组在对照组治疗基础上口服布拉氏酵母菌散。两组均连续治疗4～7 d。观察两组临床治疗效果及治疗前后患儿外周血T淋巴细胞亚群水平变化。
结果：观察组治疗总有效率为95.5%(42/44)，显著高于对照组75.0%(33/44)，差异有统计学意义(P<0.05)。观察组治疗后CD3+、CD4+/CD8+、CD4+水平均显著高于对照组，CD8+水平显著低于对照组，差异有统计学意义(P<0.05)。
结论：布拉氏酵母菌散治疗小儿急性腹泻可提高临床疗效，在一定程度上改善患儿细胞免疫功能，提高疾病预后，具有推广价值。

关键词: 急性腹泻, 细胞免疫功能, 布拉氏酵母菌散, 儿童

Abstract: Objective:To study the clinical effect of saccharomyces boulardii sachets in children with acute diarrhea and its impact on the cellular immune function.
Methods:A total of 88 children with acute diarrhea treated from May 2013 to May 2014 in our hospital were selected. The subjects were divided into control group and test group according to different therapies, 44 cases in each group. The control group received the conventional therapy; the test group was given the conventional therapy and saccharomyces boulardii. The treatment lasted for 4 to 7 days. The clinical effect and the level of peripheral blood T-lymphocyte cell were observed.
Results：The total effective rate of test group(95.5%,42/44) was significantly higher than that of control group(75.0%,33/44)(P＜0.05); after treatment, the level of CD3+, CD4+/CD8+ and CD4+ of test group was significantly higher than that of control group(P＜0.05); the level of CD8+ of test group was significantly lower than that of control group(P＜0.05).
Conclusion：For children with acute diarrhea, the saccharomyces boulardii sachets can improve the clinical effect, the cellular immune function and the children's prognosis. It is worthy of promotion.

Key words: Acute diarrhea, Cellular immune function, Saccharomyces boulardii sachets, Children