ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (5): 442-446.doi: 10.3969/j.issn.1674-3865.2020.05.021

• 临床研究 • 上一篇    下一篇

基于聚类分析及关联规则探讨中医药治疗小儿鼻鼽的用药规律

徐克菲，陈瑶，邓丽华，周用   

  1. 430000 武汉，湖北省中医院(湖北省中医药研究院、湖北中医药大学附属医院)儿科(徐克菲，陈瑶，邓丽华)，肿瘤科(周用)
  • 收稿日期:2020-05-16 出版日期:2020-10-25 上线日期:2020-10-25
  • 通讯作者: 周用，E-mail：276402194@qq.com
  • 作者简介:徐克菲(1984-)，女，医学硕士，主治医师。研究方向：中西医结合治疗儿科呼吸系统疾病

Study on medication laws of Chinese medicine in the treatment of allergic rhinitis in infants based on cluster analysis and association rules

XU Kefei,CHEN Yao,DENG Lijun,ZHOU Yong   

  • Received:2020-05-16 Published:2020-10-25 Online:2020-10-25
  • Contact: ZHOU Yong，E-mail：276402194@qq.com

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摘要： 目的 探讨近20余年以来中医药治疗小儿鼻鼽的用药规律。 方法 收集1998~2019年收录于中国学术期刊全文数据库、中文科技期刊数据库、万方数据知识服务平台，中医药治疗小儿鼻鼽的临床研究文献。将符合筛选标准的文献进行数据提取，对药物使用频次、功效分类、性味归经等进行描述性统计，药物聚类分析及关联分析。 结果 中医药治疗小儿鼻鼽最常用的药物为解表药和补虚药，并以发散风寒药及补气药为主，最常使用药物的性味归经是温性，辛、甘和苦味，归肺经、脾经、胃经、肝经和心经。形成4个聚类方剂，分别是：C1：白术、黄芪、防风；C2：苍耳子、白芷、辛夷、川芎、细辛；C3：乌梅、五味子、桂枝、麻黄；C4：茯苓、党参、甘草。 结论 通过对小儿鼻鼽用药规律的总结，临床上治疗多见以玉屏风散合苍耳子散加减，并结合相关临床症状辨证用药。

关键词: 鼻鼽, 中医药, 聚类分析, 关联规则, 用药规律, 儿童

Abstract: Objective To study the medication laws of Chinese medicine in the treatment of allergic rhinitis in infants in the past 20 years. Methods The clinical research literatures on Chinese medicine treatment for allergic rhinitis in infants were collected from China Academic Journal Full text Database, Chinese Science and Technology Journal Database and Wanfang Data Knowledge Service Platform. The data were extracted from the literatures that meet the screening criteria. Descriptive statistics was made on the frequency of drug use, and the effect, classification, nature and taste of the drugs and the meridians affected, and then cluster analysis and association analysis were performed. Results The most commonly used drugs in the treatment of infants with allergic rhinitis were exterior releasing drugs and tonic medicines, mainly those dispersing wind cold and tonifying Qi. The medicines most commonly used were warm in nature and pungent, sweet and bitter in taste, and the meridians that were affected were those of lungs, spleen, stomach, liver and heart. Four cluster prescription were formulated and they were C1(Atractylodes macrocephala, Astragalus, Fangfeng),C2(Xanthium sibiricum, Radix Angelicae dahuricae, Xinyi, Chuanxiong, Asarum),C3(Wumei, Schisandra, Guizhi, ephedra),C4(Poria, Codonopsis,Licorice). Conclusion The summary of the medication laws in the treatment of infants with allergic rhinitis shows that in clinical treatment Yupingfeng powder combined with Xanthium powder(modified) is commonly used, and differentiation medication is performed based on the relevant clinical symptoms.

Key words: Allergic rhinitis, Traditional Chinese medicine, Cluster analysis, Association rules, Medication laws, Children