ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (1): 55-57.doi: 10.3969/j.issn.1674-3865.2017.01.017

• 临床研究 • 上一篇    下一篇

三联疗法治疗小儿功能性消化不良并幽门螺杆菌感染阳性的疗效观察

吴瑕，王圣广   

  1. 518055 广东 深圳，深圳市南山区西丽人民医院儿科
  • 出版日期:2017-02-25 发布日期:2017-12-18
  • 通讯作者: 吴瑕，E-mail：chunhuaqiu101@sina.com
  • 作者简介:吴瑕(1978-)，女，医学硕士，主治医师。研究方向：小儿消化系统疾病的诊治

Triple therapy for children with functional dyspepsia complicated by positive Helicobacter pylori infection: an observation on the effect

WU Xia，WANG Shengguang   

  1. Xili People's Hospital of Nanshan District, Shenzhen 518055，China
  • Online:2017-02-25 Published:2017-12-18

PDF (PC)

115

摘要：
目的: 观察三联疗法治疗小儿功能性消化不良并幽门螺杆菌(Hp)感染阳性的效果。
方法: 2014年3月至2016年3月深圳市南山区西丽人民医院儿科收治住院的功能性消化不良并Hp感染患儿116例，随机分为观察组和对照组各58例。对照组口服多潘立酮治疗，观察组在此基础上应用三联疗法(奥美拉唑+克拉霉素+阿莫西林)，10 d为1个疗程。观察两组患儿临床疗效、治疗后Hp根除情况及用药期间的不良反应情况。
结果: 观察组总有效率为91.4%(53/58)，高于对照组74.1%(43/58)，差异有统计学意义(P<0.05)。观察组Hp根除率为94.8%(55/58)，显著高于对照组51.7%(30/58)，差异有统计学意义(P<0.01)。两组用药期间的不良反应发生率比较差异无统计学意义(P>0.05)。
结论: 三联疗法治疗小儿功能性消化不良并Hp感染阳性疗效确切，安全性较佳，适于临床应用。

关键词: 功能性消化不良, 三联疗法, 幽门螺杆菌, 儿童

Abstract:
Objective: To observe the effect of triple therapy for children with functional dyspepsia complicated by positive Helicobacter pylori(Hp) infection.
Methods: From Mar. 2014 to Mar. 2016, a total of 116 children with functional dyspepsia complicated by Hp infection were hospitalized for treatment in Xili Children's Hospital of Nanshan District in Shenzhen City, who were randomly divided into two groups: observation group(58 cases) and control group(58 cases). The control group was given domperidone orally taken, and for the observation group, triple therapy(omeprazole+clarithromycin+amoxicillin) was performed in addition to the treatment for the control group, 10 days as a treatment course. Observe the clinical effect, Hp eradication after treatment and the adverse reactions in the two groups.
Results: The total effective rate of observation group was 91.4%(53/58), higher than that of the control group 74.1%(43/58), the difference being statistical(P<0.05). The Hp eradication rate in observation group was 94.8%(55/58), significantly higher than that in the control group(51.7%,30/58) and there was statistical difference(P<0.01). There was no statistical difference on the rate of adverse reactions between the two groups during treatment(P>0.05).
Conclusion: Triple therapy is quite effective and safe in the treatment of children with functional dyspepsia complicated by positive Hp infection, and should be clinically used.

Key words: Functional dyspepsia, Triple therapy, Helicobacter pylori, Children