ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2020, Vol. 12 ›› Issue (6): 518-.

• 临床研究 • 上一篇    下一篇

不同胎龄早产儿出生早期振幅整合脑电图变化特点分析

魏恩焕，杨惠，林惠香   

  1. 365000 福建 三明，福建医科大学附属三明第一医院NICU
  • 出版日期:2020-12-25 发布日期:2021-05-14
  • 通讯作者: 魏恩焕，E-mail：weh159@126.com
  • 作者简介:魏恩焕(1974-)，男，主任医师。研究方向:新生儿危重症急救

Analysis of the characteristics of amplitude integrated EEG at early stage after birth in preterm infants of different gestational ages

WEI Enhuan，YANG Hui，LIN Huixiang.   

  1. The First Affiliated Hospital of Sanming，Fujian Medical University，Sanming 365000，China
  • Online:2020-12-25 Published:2021-05-14

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摘要： 目的：探讨不同胎龄早产儿出生早期振幅整合脑电图（aEEG）的变化特点。
方法：选取2014年1月至2016年12收住三明第一医院NICU 209例不同胎龄的早产儿，根据胎龄不同分为6组，采用NicoletOne脑功能监测仪分别在生后24 h内连续监测其aEEG波谱带的变化，对不同胎龄早产儿aEEG背景连续性、睡眠觉醒周期、下边界电压振幅和窄带宽进行回顾性分析，探讨其变化规律。
结果：（1）209例早产儿aEEG波形连续性显示胎龄＜28周组全部呈高度非连续性，随胎龄的增加，连续性电压所占比例逐渐上升。各组间比较差异有统计学意义（P<0.01）。（2）胎龄＜28周组没有肉眼可见的睡眠周期变化，随胎龄增加睡眠周期出现的频率逐渐增加且成熟，各胎龄组比较差异有统计学意义(P<0.01)。（3）随胎龄增加，波谱带下界振幅有升高趋势，早产儿各胎龄组间比较，下界振幅值差异有统计学意义(P<0.01)，带宽趋于变窄，早产儿各胎龄组间比较，各组间差异有统计学意义(P<0.01)。
结论：早产儿的发育过程不同胎龄阶段aEEG具有一定规律性，为早产儿的脑功能临床判断提供一定的参考依据。

关键词: 早产儿, 振幅整合脑电图, 胎龄, 脑功能

Abstract: Objective：To investigate the characteristics of amplitude integrated electroencephalogram(aEEG) at early stage after birth in preterm infants of different gestational ages(GA).
Methods：From January 2014 to December 2016, 209 preterm infants of different gestational ages were treated in the First Affiliated Hospital of Sanming of Fujian Medical University, who were divided into 6 groups according to the gestational age. NicoletOne brain function monitor was used to monitor the changes of aEEG within 24 hours after birth. The aEEG background continuity,sleepingwaking cycle, lower boundary voltage amplitude and bandwidth of the narrow band were retrospectively analyzed to study the regularity of the changes.
Results：The aEEG wave form continuity of 209 preterm infants showed that: (1)In the group with GA<28 weeks, all of them were highly discontinuous,and with the increase of GA, the proportion of continuous voltage gradually increased. There was significant difference among the groups(P<0.01). (2)There was no noticeable changes in the sleep cycle in the group with GA<28 weeks. With the increase of GA, the frequency of sleep cycle gradually increased and matured, and there was a significant difference among the GA groups(P<0.01). (3) With the increase of GA, the amplitude of the lower boundary of the spectral band increased. The difference in the amplitude of the lower boundary among the groups of preterm infants was statistically significant(P<0.01); the bandwidth tended to become narrow. The difference among the groups of preterm infants was statistically significant(P<0.01).
Conclusion：The aEEG shows some specific regularity at different GA in preterm infants，which provides a certain reference for clinical judgment of brain function in premature infants.

Key words: Premature infants, Amplitude integrated electroencephalogram, Gestational age, Brain function