关键词: 大叶性肺炎, 支原体感染, 人参五味子汤, 阿奇霉素, 临床疗效, 儿童

Abstract: Objective：To observe the clinical efficacy of Ginseng-Schisandrae decoction combined with intravenous azithromycin in the treatment of children with lobar pneumonia caused by mycoplasma infection (syndrome of qi deficiency of lung and spleen).
Methods：From January to December 2019,90 cases of lobar pneumonia (syndrome of qi deficiency of lung and spleen) caused by mycoplasma infection admitted to Pediatric Department in Wuhu Traditional Chinese Medicine Hospital were divided into treatment group and control group according to random number table method, with 45 cases in each group. Both groups were treated with azithromycin for anti-infection and symptomatic treatment, and the observation group was also treated with Ginseng-Schisandrae decoction. After 1 week of treatment, the clinical symptoms, signs and hospitalization time of the two groups were compared. The improvement in the scores of TCM syndrome of qi deficiency of lung and spleen before and after treatment,the improvement in serum inflammatory indicators(white blood cell count, neutrophils, C-reactive protein) before and after treatment,and the occurrence of adverse reactions were compared, and the clinical efficacy of the two groups were counted.
Results：After treatment, the clinical symptoms, signs and hospitalization time in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05).The scores of primary and secondary symptoms of syndrome of qi deficiency of lung and spleen in the two groups were lower after treatment than before treatment, and those in the observation group were lower than those in the control group, with statistically significant differences(P<0.05).The serum inflammatory indicators (white blood cell count, neutrophils, C-reactive protein) of the two groups after treatment were all lower than those before treatment, and the serum inflammatory indicators of the observation group were all lower than those of the control group, with statistically significant differences(P<0.05).There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05).
Conclusion：For the children with lobar pneumonia caused by mycoplasma infection (syndrome of qi deficiency of lung and spleen), giving Ginseng-Schisandrae decoction on the basis of intravenous azithromycin treatment can significantly improve clinical symptoms and signs, shorten the length of hospital stay, reduce inflammatory reactions and reduce the use of antibiotics, and It is safer.

Key words: Lobar pneumonia, Mycoplasma infection, Ginseng-Schisandrae decoction, Azithromycin, Clinical efficacy, Children