ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2023, Vol. 15 ›› Issue (4): 283-290.doi: 10.3969/j.issn.1674-3865.2023.04.002

• 儿童抽动障碍康复专栏 • 上一篇    下一篇

中国儿童抽动障碍预后影响因素的系统评价

郭徵艺, 阳柯佳, 雷静, 曾永渐, 郭芝东, 孙香娟   

  1. 610075 成都，成都中医药大学临床医学院2021级中医儿科学专业研究生（郭徵艺，阳柯佳，雷静，曾永渐，郭芝东）；成都中医药大学附属医院儿科（孙香娟）

  • 收稿日期:2023-05-31 出版日期:2023-08-25 上线日期:2023-08-25
  • 通讯作者: 孙香娟，E-mail：sunxiangjuan@cdutcm.edu.cn

Risk factors influencing the prognosis of tic disorders in Chinese children: a systematic review

GUO Zhiyi, YANG Kejia, LEI Jing, ZENG Yongjian, GUO Zhidong, SUN Xiangjuan   

  1.  Clinical Medical College of Chengdu University of Traditional Chinese Medicine，Chengdu 610075，China
  • Received:2023-05-31 Published:2023-08-25 Online:2023-08-25
  • Contact: SUN Xiangjuan，E-mail：sunxiangjuan@cdutcm.edu.cn

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摘要： 目的 系统评价中国儿童抽动障碍预后的影响因素。方法 计算机检索PubMed、EMbase、The Cochrane Library、Web of Science、CBM、维普、万方以及中国知网数据库，全面收集中国儿童抽动障碍预后影响因素的观察性研究，检索时限均为从建库至2022年4月。由两名研究员独立进行文献筛选、资料提取，并选用纽卡斯尔-渥太华量表(NOS)进行纳入文献的质量评价。采用RevMan 5.4软件进行Meta分析。结果 检索文献共3 572篇，最终纳入10篇，包含2项病例对照研究和8项队列研究，共包含1 699例中国抽动障碍患儿。Meta分析结果显示，精神、神经疾病家族史[OR=3.17,95%CI(1.51,6.66)]、共患病[OR=2.55,95%CI(1.68,3.87)]、病情反复频数[OR=3.65,95%CI(2.06,6.48)]、病情严重程度[OR=1.52,95%CI(1.19,1.94)]、反复呼吸道感染[OR=1.33,95%CI(1.22,1.44)]、家庭环境[OR=3.00,95%CI(1.50,5.99)]是影响中国儿童抽动障碍预后的危险因素。结论 精神、神经疾病家族史、共患病、病情反复频数、病情严重程度、反复呼吸道感染、家庭环境与中国儿童抽动障碍预后不佳相关。 

关键词: 抽动障碍, 预后, 影响因素, 系统评价

Abstract: Objective To systematically evaluate the risk factors influencing the prognosis of tic disorders(TD) in Chinese children.Methods The observational studies on the factors affecting the prognosis of children with TD were retrieved in electronic Chinese and English databases from their inception to April 2022, including PubMed, EMbase, The Cochrane Library, Web of Science, CBM, VIP, Wanfang and CNKI. Two researchers independently screened the literature, extracted the data, and evaluated the included literatures using NOS scale. RevMan 5.4 software was used for meta-analysis.Results A total of 3 572 articles were retrieved, and 10 articles were finally included, including 2 case-control studies and 8 cohort studies, with a total of 1 699 TD children. The results of Meta-analysis showed that family history of mental and neurological diseases［OR=3.17,95%CI(1.51,6.66)］, comorbidity［OR=2.55,95%CI(1.68,3.87)］, frequency of disease recurrence ［OR=3.65,95%CI(2.06,6.48)］, disease severity ［OR=1.52,95%CI(1.19,1.94)］, repeated respiratory infection ［OR=1.33,95%CI(1.22,1.44)］, and family environment［OR=3.00,95%CI(1.50,5.99)］ were risk factors influencing the prognosis of tic disorders in Chinese children.Conclusion Family history of mental and neurological disorders, comorbidities, frequency of TD recurrence, severity of disease, recurrent respiratory infection and family environment are associated with poor prognosis of tic disorders in Chinese children.

Key words:

Tic disorders, Prognosis, Influencing factors, Systematic review