ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2022, Vol. 14 ›› Issue (6): 512-516.doi: 10.3969/j.issn.1674-3865.2022.06.012

• 临床研究 • 上一篇    下一篇

肺炎支原体和呼吸道合胞病毒所致首次喘息婴幼儿临床特点及细胞因子表达比较

单玉霞, 陈海霞, 朱紫微, 迟磊, 宇璐   

  1. 单玉霞（1975-），女，主任医师。研究方向：小儿呼吸系统疾病的诊治
  • 收稿日期:2022-05-12 出版日期:2022-12-25 上线日期:2022-12-25
  • 通讯作者: 陈海霞，E-mail：13942005924@163com
  • 基金资助:
    2019年辽宁省自然基金指导计划项目（2019-ZD-1013）

Comparison of clinical features and cytokines in infants and young children with the first wheezing caused by Mycoplasma pneumoniae and respiratory syncytial virus

SHAN Yuxia, CHEN Haixia, ZHU Ziwei, CHI Lei, YU lu   

  1. Respiratory Department，Dalian Women's and Children's Medical Center(Group)，Dalian 116012，China

  • Received:2022-05-12 Published:2022-12-25 Online:2022-12-25
  • Contact: CHEN Haixia，E-mail：13942005924@163com

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摘要： 目的 探讨肺炎支原体（MP）和呼吸道合胞病毒（RSV）所致首次喘息婴幼儿临床特点及干扰素-γ（IFN-γ，Th1细胞因子）、白细胞介素-4和白细胞介素-33（IL-4，IL-33，Th2细胞因子）表达差异。方法 收集2019年1月至2020年12月在本院呼吸科住院确诊MP和RSV感染所致首次喘息婴幼儿82例和68例分别为MP感染组、RSV感染组；选择同期健康婴幼儿30例为对照组。比较MP感染组及RSV感染组临床特点；分别检测3组外周血IFN-γ、IL-4、IL-33含量并计算IFN-γ/IL-4、IFN-γ/IL-33比值并进行比较。结果 与RSV感染组相比，MP感染组发病年龄大、喘息病程短、发热者占比少、白细胞计数水平高、淋巴细胞占比低、总IgE水平高、CRP水平低，差异有统计学意义（P<005）；与对照组相比，MP感染组和RSV感染组IFN-γ水平降低、IL-4及IL-33水平升高、IFN-γ/IL-4及IFN-γ/IL-33比值降低，差异有统计学意义（P<005）；与MP感染组相比，RSV感染组IFN-γ水平降低、IL-4及IL-33水平升高、IFN-γ/IL-4及IFN-γ/IL-33比值降低，差异有统计学意义（P<005）。结论 细胞因子IFN-γ、IL-4、IL-33以及Th1/Th2免疫失衡（Th2免疫应答优势）可能参与了MP感染和RSV感染所致首次喘息婴幼儿发病过程。


关键词: 肺炎支原体, 呼吸道合胞病毒, 婴幼儿首次喘息, 细胞因子

Abstract: Objective To explore the clinical characteristics and the expression of interferon-γ（IF-γ，Th1 cytokine），interleukin-4 and interleukin-33（IL-4，IL-33，Th2 cytokine） of infants and young children with the first wheezing caused by Mycoplasma pneumoniae（MP） and respiratory syncytial virus（RSV）. Methods Totally 82 cases and 68 cases with respectively confirmed MP and RSV infection causing first-time wheezing in infants and young children were collected from January 2019 to December 2020，and they were regarded as MP and RSV infection group，and 30 healthy infants and young children were selected as healthy control group. The clinical characteristics of the MP group and the RSV group were compared，and the IFN-γ，IL-4 and IL-33 contents of the peripheral blood of the three groups were detected . The ratios of IFN-γ/IL-4 and IFN-γ/IL-33 were calculated and compared. Results Compared with the RSV infection group，MP infection group had an older age，shorter wheezing course，fewer proportion of fever,higher level of WBC count,lower proportion of lymphocyte，higher total IgE level，lower CRP level，with a statistical difference between the two groups（P＜0.05）.Compared with the health control group，IFN-γ levels decreased，IL-4 and IL-33 levels increased，and IFN-γ/IL-4 and IFN-γ/IL-33 ratios decreased in MP and RSV infection groups，and the differences were statistically significant（P＜0.05）.Compared with the MP infection group，the RSV infection group had lower IFN-γ levels，higher IL-4 and IL-33 levels，and lower ratio of IFN-γ/IL-4 and IFN-γ/IL-33, with a statistical difference between the two groups（P＜0.05）. Conclusion Cytokines IFN-γ，IL-4，IL-33 and Th1/Th2 imbalance with Th2 advantaged response may be involved in the first wheezing caused by MP and RSV infection in infants and young children.


Key words:

Mycoplasma pneumonia, Respiratory syncytial virus, Infants and young children with the first wheezing, Cytokines