ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2021, Vol. 13 ›› Issue (6): 511-514.doi: 10.3969/j.issn.1674-3865.2021.06.014

• 临床研究 • 上一篇    下一篇

IgA血管炎患儿外周血血小板平均体积变化及临床意义

张茂霞, 马宏   

  1. 030001 太原，山西医科大学第一临床医学院2018级儿科学专业研究生（张茂霞）；山西医科大学第一医院儿科（马宏）

  • 收稿日期:2021-01-06 出版日期:2021-12-25 上线日期:2021-12-25
  • 通讯作者: 马宏，E-mail:xiaoyuanma@163.com

Changes and clinical significance of mean platelet volume in peripheral blood of children with immunoglobulin A vasculitis

ZHANG Maoxia, MA Hong   

  1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China

  • Received:2021-01-06 Published:2021-12-25 Online:2021-12-25
  • Contact: MA Hong，E-mail:xiaoyuanma@163.com

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摘要： 目的 分析IgA血管炎患儿MPV、RDW、PLT、NLR、PLR、MPR水平与IgA血管炎的关系。方法 选择2015年1月至2020年9月山西医科大学第一医院诊治的IgA血管炎患儿179例为研究对象,根据临床特征是否有多系统损害进行分组,多系统损害型IgA血管炎患儿89例为观察组,普通型IgA血管炎患儿90例为对照组。采用双变量Pearson直线相关性分析;采用多因素Logistic回归分析多系统损害的影响因素;绘制ROC曲线,进行分析。结果 观察组MPV、MPR水平均低于对照组,PLT、PLR水平均高于对照组;两组MPV水平与PLT呈负相关,与MPR呈正相关,MPV是多系统损害的影响因素。以观察组PLT、PLR、MPV水平绘制ROC曲线,其曲线下面积分别为0.128、0.674、0.621,最佳截断值分别是8.25、308.50、123.17。结论 外周血MPV、PLT、PLR可能在评估IgA血管炎多系统损害方面有一定的意义。

关键词: IgA血管炎, 多系统损害, 血小板平均体积

Abstract: Objective To analyze the relationship between MPV, RDW, PLT, NLR, PLR, MPR level and IgA vasculitis(IgAV) in children with IgAV.Methods A total of 179 children with IgAV were included as the research subjects, who were diagnosed and treated in the First Hospital of Shanxi Medical University from Jan. 2015 to Sep. 2020. They were divided into two groups based on whether there was multi-system damage: 89 IgAV children with multi-system damage in the observation group and 90 children with common IgAV in the control group. Pearson bivariate linear correlation analysis was adopted.Multivariate Logistic regression analysis was used to analyze the influencing factors of multi-system damage. ROC curve was drawn to make the analysis.Results The levels of MPV and MPR in the observation group were lower than those in the control group, while the levels of PLT and PLR in the observation group were higher than those in the control group(P<0.05).The level of MPV of the two groups were negatively correlated with PLT and positively correlated with MPR; MPV level was the influencing factor of multi-system damage. The levels of PLT, PLR and MPV of observation group were used to draw the ROC curve. The AUC of MPV, PLT and PLR were 0.128, 0.674 and 0.621, respectively, and the best cut-off values were 8.25, 308.50 and 123.17, respectively.Conclusion MPV, PLT and PLR in peripheral blood may have certain significance in evaluating the multi-system damage of IgAV.

Key words:

Immunoglobulin A vasculiti, Multiple-system damage, Mean platelet volume