ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (1): 10-12.doi: 10.3969/j.issn.1674-3865.2016.01.004

• 临床论著 • 上一篇    下一篇

支气管哮喘急性发作期患儿血清嗜酸性粒细胞阳离子蛋白与IgE的相关性研究

尚莉丽，项李娥   

  1. 230038 合肥，安徽中医药大学第一附属医院儿科
  • 出版日期:2016-02-25 发布日期:2018-11-19
  • 通讯作者: 尚莉丽，E-mail:kyksh@126.com
  • 作者简介:尚莉丽（1963-），女，医学硕士，主任医师，硕士研究生导师。研究方向：中医药防治小儿呼吸系统疾病
  • 基金资助:
    安徽省自然科学基金项目（11040606M186）

Study on the relationship between serum eosinophil cationic protein and IgE in children with bronchial asthma in acute stage

SHANG Lili，XIANG Li'e   

  1. Pediatric Department，the First Affiliated Hospital of Anhui TCM University，Hefei 230038，China
  • Online:2016-02-25 Published:2018-11-19

PDF (PC)

107

摘要：
目的：初步探讨支气管哮喘急性发作期患儿血清嗜酸性粒细胞阳离子蛋白（ECP）与免疫球蛋白E（IgE）的相关性。
方法：2013年1月至12月安徽中医药大学第一附属医院儿科收治住院的轻中度支气管哮喘急性发作期患儿30例作为观察组，同期选取30例健康体检的儿童作为健康对照组。采用ELISA双抗体夹心法测定两组血清ECP和IgE的水平。
结果：观察组血清ECP、IgE显著高于健康对照组，差异有统计学意义（P＜0.01）。观察组中ECP与IgE呈正相关关系（r=0.471，P＜0.01）。
结论：测定IgE、ECP水平能反映气道炎症的严重程度，可作为支气管哮喘气道炎症检测的指标。

关键词: 哮喘, 嗜酸性粒细胞阳离子蛋白, IgE, 儿童

Abstract:
Objective：To study the correlation between serum eosinophil cationic protein(ECP) and immunoglobulin E(IgE) in children with acute attack of bronchial asthma.
Methods：From January to December 2013，30 cases of mild-to-moderate bronchial asthma children in acute phase who were treated in the First Affiliated Hospital of Anhui Traditional Chinese Medical University were chosen as observation group.At the same time select 30 cases of healthy children as the healthy control group.Use the double antibody ELISA method to determine serum ECP and IgE level of two groups.
Results：The ECP and IgE in the observation group were significantly higher than those in the control group(P＜0.01).ECP and IgE in the observation group had significantly positive correlation(r=0.471，P＜0.01).
Conclusion：Determination of serum IgE，ECP level can reflect the severity of airway inflammation，so they can be used as indexes of airway inflammation detection in bronchial asthma.

Key words: Asthma, ECP, IgE, Children