ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (1): 79-81.doi: 10.3969/j.issn.1674-3865.2016.01.029

• 临床研究 • 上一篇    下一篇

不同剂量丙种球蛋白治疗儿童重型手足口病疗效观察

廖先辉   

  1. 563000 贵州 遵义，遵义市妇幼保健院儿科
  • 出版日期:2016-02-25 发布日期:2018-11-19
  • 作者简介:廖先辉(1972-)，女，主治医师。研究方向：小儿消化系统疾病的诊治，E-mail：1148834754@qq.com

Observation on the effect of different doses of gamma globulin in the treatment of children with severe

HFMDLIAO Xianhui   

  1. Department of Pediatrics，Zunyi Maternity and Child Health Care Hospital，Zunyi 563000，China
  • Online:2016-02-25 Published:2018-11-19

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摘要：
目的：观察不同剂量丙种球蛋白治疗重型小儿口足病的临床疗效。
方法：遵义市妇幼保健院儿科2013年6月至2015年6月收治2期、3期手足口病患儿96例，随机分为小剂量组和大剂量组各48例。两组患儿在常规治疗和对症治疗的基础上静脉注射不同剂量丙种球蛋白，小剂量组注射剂量为1 g/kg，大剂量组注射剂量为2 g/kg，比较两组患儿临床症状消失时间、临床治愈时间、住院时间、并发症以及经济效益。
结果：两组患儿临床症状消失时间、临床治愈时间、住院时间比较差异无统计学意义(P＞0.05)；大剂量组患儿的并发症发生率为16.7%(8/48)，高于对照组2.1%(1/48)，差异有统计学意义(P＜0.05)；另外小剂量组治疗费用更低。
结论：不同剂量的丙种球蛋白治疗重型手足口病疗效均显著且相近，而剂量为1 g/kg的丙种球蛋白治疗费用更低、患儿并发症发生率低，值得推广和运用。

关键词: 重型手足口病, 丙种球蛋白, 临床疗效, 儿童

Abstract:


Objective：To observe the clinical effect of gamma globulin at different doses in the treatment of children with severe HFMD.
Methods：A total of 96 children with HFMD at stage Ⅱ and Ⅲ were treated in Zunyi Maternity and Child Health Care Hospital from June 2013 to June 2015，and they were divided randomly into two groups:the small-dose group and the large-dose group，with 48 cases in each group.The two groups were given conventional and symptomatic treatment，and in addition to that，they were injected intravenously different doses of gamma globulin，with 1 g/kg for the small-dose group and 2 g/kg for the large-dose group.Compare the time for clinical symptoms to disappear，the time of being clinically cured，the hospital stay，the complications and the hospitalization expenses between the two groups.
Results：There was no statistical difference in the time for clinical symptoms to disappear，the time of being clinically cured and the hospital stay(P＞0.05).The complication incidence was 16.7%(8/48) in the large-dose group，higher than the small-dose one，which was 2.1%(1/48)，and the difference was statistical significance(P＜0.05).The expense in the small-dose group was lower.
Conclusion：The effect of gamma globulin at different doses is similar and significant in the treatment of severe HFMD.When the dose is 1 g/kg，the treatment expense is lower and the complication incidence is lower，so it is worthy of being clinically applied.

Key words: Severe HFMD, Gamma globulin, Clinical effect, Child