ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 556-560.doi: 10.3969/j.issn.1674-3865.2015.06.008

• 临床研究 • 上一篇    下一篇

喜炎平注射液治疗儿童社区获得性肺炎前瞻性多中心随机对照临床研究

张秀英，魏巍，姜永红，王孟清，常克，李伟伟，吴振起,李晓   

  1. 110032 沈阳，辽宁中医药大学附属医院儿科（张秀英，吴振起，魏巍，李晓）；200032 上海，上海中医药大学附属龙华医院儿科（姜永红）；410007 长沙,湖南中医药大学第一附属医院儿科（王孟清）；610072 成都,成都中医药大学附属医院儿科（常克）；50023 南宁,广西中医学院第一附属医院儿科（李伟伟）
  • 出版日期:2015-12-25 上线日期:2018-11-19
  • 通讯作者: 张秀英，E-mail：1370264413@qq.con
  • 作者简介:张秀英（1978-），女，2013级博士研究生在读，主治医师。研究方向：中医药防治病毒性疾病
  • 基金资助:
    国家科技部十二五重大新药创制专项（2014ZX09201025）

A prospective randomized controlled multicenter trial of Xiyanping injection in treatment of children with pneumonia

ZHANG Xiuying,WEI Wei,JIANG Yonghong,WANG Mengqing,CHANG Ke,LI Weiwei,WU Zhenqi,LI Xiao   

  1. The First Affiliated Hospital of Liaoning University of TCM,Shenyan 110032,China.
  • Published:2015-12-25 Online:2018-11-19

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摘要：
目的: 评价喜炎平注射液治疗儿童社区获得性肺炎的有效性和安全性。
方法: 采用前瞻性、多中心、随机对照临床研究。选取5家医院的298例肺炎患儿随机分为对照组和观察组，观察组给予喜炎平注射液联合基础方法治疗，对照组单采用基础方法治疗，观察两组患儿的疾病总体疗效、中医证候疗效，发热、咳嗽症状起效消失时间，治疗前后中医主症积分情况，停药30 d后呼吸系统疾病及中医主症发生的情况。
结果: 两组患儿在疾病的总体疗效，中医证候疗效，发热、咳嗽起效消失时间，风热闭肺证和痰热闭肺证治疗后主症积分及停药30 d后呼吸系统疾病和中医主症的发生率等方面相比较，差异均有统计学意义（P<0.05）。观察组未见任何不良反应。
结论: 喜炎平注射液是一种适用于儿童肺炎的具有解热、止咳作用的中成药注射液，其疗效可靠，安全性好，值得在儿科推广使用。

关键词: 肺炎, 喜炎平注射液, 治疗应用, 多中心试验, 随机对照研究, 儿童

Abstract:
Objective：To evaluate the effects and safety of Xiyanping injection for treating children with pneumonia.
Methods：A prospective randomized controlled multicenter trial was used.298 cases of Children with pneumonia in five centers hospitalization were studied.The experimental group was given Xiyanping injection combined with basic treatment,and the control group only treated by basic treatment,then evaluat these two groups of children with  the disease in general curative effect, Chinese medicine syndrome efficacy, symptoms of fever, cough effect disappear time, before and after treatment of TCM primary symptom integral, discontinuation after 30 d happened respiratory system diseases and primary symptom of TCM.
Results：Two groups of children in the overall efficacy of disease, syndromes curative effect, fever, cough effect disappeared time, primary symptom score after therapy , the incidence of respiratory system diseasesl and primary symptom of traditional Chinese medicine after 30 d compared differences were statistically significant (P<0.05). Observation group did not see any adverse reaction.
Conclusion：Xiyanping injection combined with basic therapy on the treatment of pneumonia in children is significantly better than the control group,it's safe and effective,the prognosis is good and worthy of promotion inclinical use.

Key words: Pneumonia, Xiyanping injection, Multicenter trials, Randomized controlled trials, Children