ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 606-608.doi: 10.3969/j.issn.1674-3865.2015.06.026

• 临床研究 • 上一篇    下一篇

匹多莫德口服液预防小儿反复呼吸道感染临床疗效观察

郑文莉，关雪，白彬彬，龙凤   

  1. 066100 河北 秦皇岛，解放军北京军区第二八一医院儿科
  • 出版日期:2015-12-25 发布日期:2018-11-19
  • 通讯作者: 郑文莉，E-mail：zwlszwl@sina.com
  • 作者简介:郑文莉（1964-），女，主任医师。研究方向：小儿呼吸系统疾病的诊断与治疗

Clinical observation on the effect of pidotimod in preventing infantile recurrent respiratory infection

ZHENG Wenli,GUAN Xue,BAI Binbin,LONG Feng   

  1. People's Liberation Army 281 Hospital，Qinhuangdao 066100，China
  • Online:2015-12-25 Published:2018-11-19

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摘要：
目的: 观察匹多莫德口服液治疗小儿反复呼吸道感染的临床疗效及其免疫功能的影响。
方法: 选取解放军北京军区第二八一医院2013-04/2014-04收治住院及门诊的反复呼吸道感染患儿96例，随机分为观察组和对照组各48例。对照组常规给予抗感染及对症治疗，观察组在此基础上加匹多莫德口服液，每次0.4 g，每日1～2次，疗程3个月。随访3个月比较两组临床疗效及治疗前后免疫功能变化。
结果: 观察组总有效率85.41%（41/48），显著高于对照组62.40%（30/48），差异有统计学意义（P＜0.05）。观察组再次感染病程、感染次数和抗生素使用时间显著减少，差异有统计学意义（P＜0.05）。治疗后观察组血浆IgG、IgA、IgM含量高于治疗前及对照组，差异有统计学意义（P＜0.05）；对照组治疗前后血浆IgG、IgA、IgM含量相当，差异无统计学意义（P＞0.05）。
结论: 匹多莫德口服液能增强反复呼吸道感染患儿机体免疫功能，减少感染次数，提高疗效。

关键词: 呼吸道感染, 匹多莫德口服液, 治疗应用, 免疫, 儿童

Abstract:
Objective：To observe the effect of pidotimod in the treatment of infantile recurrent respiratory infection and its influence on the immune function.
Methods：We collected 96 patients diagnosed with recurrent respiratory infection from April, 2013 to April,2014,and divided them randomly into observation and control group with 48 patients in each one. The control group was given with antiinfection and symptomatic treatment, while the other group was added pidotimod with 0.4 g qd or b.i.d, to improve their immune function. The whole treatment lasted for 3 months. We observed the effect in the two groups and the change of immune function before and after the treatment.
Results：The total effective rate of observation group was 85.41%, which was obviously higher than the control group（62.40%）；the course of secondary infection, times of recurrent infection and the duration of antibiotics use in the observation group obviously decreased；the level of IgG, IgA and IgM in the serum after using pidotimod was remarkably higher than before and higher than the level in the control group；all the difference had statistical significance（P＜0.05）. No effect was shown in the control group.ConclusionPidotimod can improve the immune function of children with recurrent infection of respiratory tract，decrease the possibilities of infection and enhance the efficiency.

Key words: Respiratory tract infection, Pidotimod, therapeutic use, Immune, Child