ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2015, Vol. 7 ›› Issue (6): 621-624.doi: 10.3969/j.issn.1674-3865.2015.06.032

• 临床研究 • 上一篇    下一篇

湿润烧伤膏联合重组人表皮生长因子与银离子抗菌敷料在小儿Ⅱ度烫伤中的应用

唐湘莲,张甜,文海韬,文佳冰   

  1. 410007 长沙，湖南省儿童医院急诊综合外科
  • 出版日期:2015-12-25 上线日期:2018-11-19
  • 通讯作者: 唐湘莲，Email: tcw143@163.com
  • 作者简介:唐湘莲（1983-），女，医学硕士，医师。研究方向：小儿普外疾病的治疗

MEBO plus rhEGF and ionic silver dressing in treatment of children with Ⅱ scald

TANG Xianglian, ZHANG Tian, WEN Haitao, WEN Jiabing   

  1. Department of Generel Emegency Surgery,Hunan Children's Hospital,Changsha 410007,China.
  • Published:2015-12-25 Online:2018-11-19

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摘要：
目的:总结湿润烧伤膏(MEBO)联合重组人表皮生长因子(rhEGF)及银离子敷料治疗小儿Ⅱ度烫伤创面的临床疗效。
方法:将116例Ⅱ度烫伤患儿分为5组，分别为MEBO创面暴露组、MEBO+rhEGF创面暴露组、MEBO创面包扎组、MEBO+rhEGF创面包扎组、MEBO+rhEGH+银离子敷料包扎组。观察各组创面痊愈时间及用药后创面愈合率、色素沉着度及瘢痕形成情况。
结果:不同治疗方式的愈合时间：MEBO+rhEGH+银离子敷料组＜ MEBO+rhEGH组＜MEBO组。治疗效果方面：MEBO+rhEGH+银离子敷料组对Ⅱ度烧伤创面的治疗效果均优于MEBO+rhEGH组和单纯使用MEBO组，平均愈合时间提前3～5 d，差异有统计学意义(P<0.01)，且MEBO+rhEGH+银离子敷料组效果也优于单纯使用MEBO组，差异有统计学意义(P<0.01)；MEBO+rhEGH+银离子敷料组患儿创面色素沉着及瘢痕形成率相对MEBO组明显减少(Ｐ<0.01)，且患儿创面愈合效果良好、较少引起色素沉着，半年后部分患者随访证实远期愈合效果好，较少引起瘢痕增生。
结论:MEBO联合rhEGF与银离子敷料治疗小儿Ⅱ度烧烫伤效果确切、预后良好，值得临床推广应用。

关键词: 烫伤, 重组人表皮生长因子, 治疗应用, 银离子, 治疗应用, 儿童

Abstract:
Objective：To investigate the therapeutic effect of MEBO plus recombination human epidermal growth factor(rhEGF) and ionic silver dressing in the treatment of children with Ⅱ scald wound.
Methods：Totally 116 cases of children with scald wound were randomly divided into five groups;the wound healing time,healing rate,pigmentation degree and scar index were observed.
Results：With different treatments,the healing time and healing rate were as follows:MEBO plus rhEGF and ionic silver dressing group＜MEBO plus rhEGF group＜MEBO group。MEBO plus rhEGF and ionic silver dressing had better effect than MEBO in the treatment of children with Ⅱ scald wound,and significantly shorten the average healing time by 3 to 5 days(P＜0.01). MEBO plus rhEGF and ionic silver dressing group was better than the MEBO plus rhEGF group(P<0.01). MEBO plus rhEGF and ionic silver dressing group had good healing effect;less pigmentation and fewer scars were seen in some patients after half a year of followup.
Conclusion：MEBO plus rhEGF and ionic silver dressing has good effect in the treatment of children with Ⅱ scald wound and the prognosis is good,which is worthy of being recommended in clinical practice.

Key words: Scald, rhEGF, therapeutic use, Ionic silver, therapeutic use, Children