ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 143-146.doi: 10.3969/j.issn.1674-3865.2018.02.016

• 临床研究 • 上一篇    下一篇

蒲地蓝消炎口服液治疗小儿手足口病临床观察及成本效果分析

张钧侠   

  1. 110500 辽宁 康平，辽宁省康平县人民医院儿科
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 作者简介:张钧侠（1968-），女，副主任医师。研究方向：小儿内科疾病的诊治，E-mail：2466293906@qq.com

Clinical observation and the cost-effectiveness analysis of the treatment with Pudilan Xiaoyan oral liquid for hand-foot-mouth disease in children

ZHANG Junxia   

  1. Kangping People's Hospital of Liaoning Province, Kangping 110500，China
  • Online:2018-04-25 Published:2018-11-19

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摘要：
目的
观察蒲地蓝消炎口服液治疗小儿手足口病的临床疗效及成本效果分析。
方法
选取2016年3月至2017年6月辽宁省康平县人民医院儿科门诊收治的普通型手足口病患儿60例，随机分为观察组和对照组各30例。观察组给予蒲地蓝消炎口服液口服及对症治疗，对照组给予重组人干扰素α1b肌肉注射和利巴韦林颗粒口服，同时给予对症治疗，5 d为1个疗程，观察两组临床疗效、症状体征（包括体温、皮疹和口腔疱疹）消退时间、并发症发生率，并进行成本效果分析。
结果
观察组愈显率为76.6%（23/30），显著高于对照组50.0%（15/30），差异有统计学意义(P<0.05)；两组总有效率比较差异无统计学意义(P>0.05)。观察组退热时间明显短于对照组，两组差异有统计学意义(P<0.05)。比较两组皮疹、口腔疱疹消退时间及并发症发生比例，差异无统计学意义(P>0.05)。观察组成本效果比值为4.56，低于对照组7.03，其药物经济学价值更高。
结论
蒲地蓝消炎口服液治疗小儿手足口病（普通型）临床疗效显著，经济简便，值得临床推广应用。

关键词: 手足口病, 蒲地蓝消炎口服液, 儿童

Abstract:
objective
Clinical effect and cost-effectiveness analysis of the treatment with Pudilan Xiaoyan oral liquid for hand-foot-mouth disease in children.
Methods
Sixty cases of hand-foot-mouth disease(common type) were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given Pudilan Xiaoyan oral liquid and symptomatic treatment, while the control group was given recombinant interferon α-1b by intramuscular injection and ribavirin granules for orally taking, and symptomatic treatment was also given, 5 days as 1 course; observe the clinical efficacy, the time for symptoms and signs(including temperature, rash and oral herpes) to subsided, and the incidence rate of complications, the cost-effectiveness analysis was carried out.
Results
The recovery rate of treatment group and control group was 76.6%(23/30) and 50.0%(15/30), respectively, and there were statistically significant differences between the two groups(P<0.05). There was no statistically significant difference in the total effective rate(P>0.05). The treatment group had a shorter fever time than the control group, and there was a statistically significant difference between the two groups(P<0.05). Comparing the time for rash and oral herpes to subsided and the incidence of complication between the two groups, there was no statistically significant difference(P>0.05).The cost-effect ratio of the two groups was 4.56 in treatment group and 7.03 in control group, and the treatment group was better than the control group(P>0.05).
Conclusion
The clinical Pudilan Xiaoyan oral liquid in treating children with hand-foot-mouth disease(common type) is remarkable, economical and convenient, which is worthy of clinical application.

Key words: Hand-foot-mouth disease, Pudilan Xiaoyan oral liquid, Children