ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2019, Vol. 11 ›› Issue (4): 301-307.doi: 10.3969/j.issn.1674-3865.2019.04.008

• 临床论著 • 上一篇    下一篇

喜炎平注射液治疗儿童呼吸道合胞病毒肺炎有效性及安全性的Meta分析

马明星,王雪峰,张秀英,李林峰,姜俊爽,宋立超   

  1. 110032 沈阳,辽宁中医药大学2017级中西医结合儿科专业研究生(马明星),2017级针灸推拿专业研究生(李林峰),2017级中医儿科专业研究生(姜俊爽),2018级中西医结合儿科专业研究生(宋立超);辽宁中医药大学附属医院儿科(王雪峰,张秀英)
  • 出版日期:2019-08-25 发布日期:2019-09-18
  • 通讯作者: 王雪峰,E-mail:lnzywxf@16.com
  • 作者简介:马明星(1993-),女,辽宁中医药大学2017级硕士研究生在读。研究方向:中医药防治病毒性疾病
  • 基金资助:
    国家科技部十二五重大新药创制专项(2014ZX09201025)

Xiyanping injection in the treatment of respiratory syncytial virus pneumonia in children Meta-analysis of effectiveness and safety

MA Mingxing,WANG Xuefeng,ZHANG Xiuying ,LI Linfeng,JIANG Junshuang,SONG Lichao   

  1. Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China
  • Online:2019-08-25 Published:2019-09-18

摘要:
目的
通过Meta分析的方法系统评价喜炎平注射液治疗儿童呼吸道合胞病毒肺炎的有效性和安全性。
方法
系统检索CNKI、VIP、CBM、Wanfang Data、PubMed、Web of Science、EMbase及The Cochrane Library数据库,检索时间截止至2019年4月30日。搜集所有的喜炎平注射液治疗儿童呼吸道合胞病毒肺炎的随机对照试验(RCTs),由2名研究员按统一标准独立完成文献筛选、信息提取、偏倚风险评价及采用RevMan 5-3软件对有效数据进行Meta分析过程。
结果
共纳入9个临床对照研究,病例共686例。Meta分析结果显示,在有效性方面,喜炎平注射液能明显提高总有效率[RR=1.18,95%CI(1.12,1.25),P<0.000 01]、显著缩短住院时间[MD=-3.01,95%CI(-3.82,-2.61),P<0.000 01],同时可缩短退热时间、咳嗽消失时间及肺部啰音消失时间,加快胸片炎症吸收时间,降低血清炎性因子水平;在安全性方面,能降低不良反应发生率[MD=0.45,95%Cl(0.25,0.82),P<0.010],差异有统计学意义。
喜炎平注射液治疗儿童呼吸道合胞病毒肺炎有效性及安全性均优于常规治疗,能明显提高临床总有效率,显著缩短住院时间,改善症状体征,降低不良反应发生率。但纳入文献数量及质量有限,还需开展更多大样本、高质量的随机对照试验对其有效性及安全性予以验证。

关键词: 呼吸道合胞病毒肺炎, 喜炎平注射液, Meta分析, 儿童

Abstract:
Objective
To systematically evaluate the efficacy and safety of Xiyanping injection in the treatment of respiratory syncytial virus pneumonia in children by meta analysis.
Methods
The CNKI, VIP, CBM, Wanfang Data, PubMed, Web of Science, EMbase and The Cochrane Library databases were systematically searched, and the search time was until April 30, 2019. Collect randomized controlled trials(RCTs) on Xiyanping injection in the treatment of children with respiratory syncytial virus pneumonia. Two researchers independently completed literature screening, information extraction and risk assessment of bias, and a Metaanalysis was made on the valid data using RevMan 5.3 software.
Results
A total of 9 clinical controlled studies were included, with a total of 686 cases. Metaanalysis showed that, in terms of effectiveness, Xiyanping injection significantly improved the total effective rate[RR=1.18, 95%CI(1.12, 1.25), P<0.000 01] and significantly shortened hospital stay[MD=-3.01, 95%CI(-3.82, -2.61), P<0.000 01]; it also shortened the time of fever, and the relief time of cough and lung rales; it accelerated the absorption time of chest inflammation and reduced serum inflammatory factor levels. In terms of safety, the incidence of adverse reactions was reduced[MD=0.45, 95%CI(0.25, 0.82), P<0.010], and the difference was statistically significant.
Conclusion
The efficacy and safety of Xiyanping injection in treating children with respiratory syncytial virus pneumonia is better than conventional treatment, which can significantly improve the total clinical effective rate, significantly shorten the hospital stay, improve symptoms and signs, and reduce the incidence of adverse reactions. However, the number and quality of the included literature is limited, and more large-sample, high-quality randomized controlled trials are needed to verify its effectiveness and safety.

Key words: Respiratory syncytial virus pneumonia, Xiyanping injection, Meta-analysis, Children