ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (4): 380-383.doi: 10.3969/j.issn.1674-3865.2016.04.003

• 实验论著 • 上一篇    下一篇

茯苓营养合剂对单纯性肥胖幼鼠体质量、血脂及组织病理学的影响

李景辉，任刚，詹杰，李晶,黄波   

  1. 110101 沈阳，辽宁医药职业学院医学营养教研室
  • 出版日期:2016-08-25 发布日期:2018-11-19
  • 通讯作者: 李景辉，E-mail：66921644@qq.com
  • 作者简介:李景辉(1977-)，女，医学硕士，讲师。研究方向：中医药膳、食品营养。
  • 基金资助:
    辽宁中医药大学职业技术学院科学研究基金项目(2009Y03)

Effect of Fuling nutrient mixture on the body weight, blood fat and histopathology of the immature rats with simple obesity

LI Jinghui，REN Gang，ZHAN Jie，LI Jing，HUANG Bo   

  1. Liaoning Vocational College of Medicine, Shenyang 110101，China.
  • Online:2016-08-25 Published:2018-11-19

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摘要：
目的：观察茯苓营养合剂对单纯性肥胖幼鼠体质量、血脂及组织病理学的影响，探索防治单纯性肥胖的新途径。
方法：40只雄性1月龄SD大鼠随机分为茯苓组(茯苓+普通饲料)，茯苓营养合剂组(茯苓+维生素B1、B2+普通饲料)，模型对照组(普通饲料)和空白对照组(普通饲料)，每组10只。茯苓组、茯苓营养合剂组、模型对照组大鼠喂养高脂饲料6周造模。观察各组大鼠体质量、体脂、血脂及组织病理学等指标。
结果：(1)给药两组大鼠体脂含量与模型对照组比较，差异无统计学意义(P>0.05)，而体质量增长值比较差异有统计学意义(P<0.05)；给药两组大鼠体质量增长值及体脂含量比较差异无统计学意义(P>0.05)。(2)给药两组大鼠及空白对照组大鼠甘油三酯含量均低于模型对照组，差异有统计学意义(P<0.01)；给药两组大鼠高密度脂蛋白含量均高于模型对照组，差异有统计学意义(P<0.05)；给药两组大鼠甘油三酯和高密度脂蛋白含量比较差异无统计学意义(P>0.05)；给药两组大鼠胆固醇和低密度脂蛋白含量与模型对照组比较，差异无统计学意义(P>0.05)。(3)茯苓组和茯苓营养合剂组大鼠肝脏的组织病理形态经治疗接近正常水平。
结论：茯苓能降低单纯性肥胖幼鼠的体质量、甘油三酯，升高高密度脂蛋白，恢复肝脏组织生理形态。

关键词: 单纯性肥胖, 茯苓, 血脂, 组织病理学, 大鼠

Abstract:
Objective：To observe the effect of Fuling nutrient mixture on the body weight, blood fat and histopathology of the immature rats with simple obesity, and explore the new way of healing the simple obesity.
Methods：Divide the 40 one-month rats into four groups, including Fuling group(Fuling+normal diet), Fuling nutrient mixture group(Fuling+vitamin B1, vitamin B2+normal diet)， model control group(normal diet) and blank control group(normal diet), each group with 10 rats. Feed the first three groups with high fat diet for 6 weeks, and make the models. Observe the following indicators of the rats：body weight, body fat, blood fat and histopathology.
Results：(1)For the two groups of young rats, Fuling(Fuling+normal diet) and Fuling nutrient mixture group(Fuling+vitamin B1，B2+normal diet), compared with the model control group， body fat content was of no statistically significant difference(P>0.05)， but there was a statistically significant difference(P<0.05) in body quality growth. Between these two groups body quality growth and body fat content were of no significant difference in statistics.(2)Triglyceride(TG) levels of those two groups and the blank control group were lower than those of model control group, the difference being significant in statistics（P＜0.01）.High density lipoprotein(HDL-C) level of the two groups was higher than that of the model group, the difference being statistically significant(P<0.05). There were no differences(P>0.05) in either triglyceride(TG) levels or high density lipoprotein(HDL-C) levels between those two groups. Compared with the model group，total cholesterol(TC) levels and low-density lipoprotein(LDL-C) levels of those two groups remained no significant difference(P>0.05) in statistics.(3)Histopathologic morphology of the liver tissues of the two groups after treatment was close to normal.
Conclusion：Fuling can decrease the weight and the triglyceride of the rats with simple obesity, increase the high-density lipoprotein, and recover the physiomorphology of the liver.

Key words: Simple obesity, Fuling, Blood fat, Histopathology, Rat