ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 619-621.doi: 10.3969/j.issn.1674-3865.2016.05.023

• 临床研究 • 上一篇    下一篇

双歧三联活菌片联合蒙脱石散治疗儿童抗生素相关性腹泻疗效观察

朱丽丽   

  1. 110101 沈阳，沈阳市苏家屯区中心医院儿科
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 作者简介:朱丽丽(1982-)，女，主治医师。研究方向：小儿内科疾病的治疗，E-mail：78208587@qq.com

Observation on the effect of Bifid Triple Viable tablet combined with montmorillonite powder in the treatment of antibiotic-associated diarrhea in children

ZHU Lili   

  1. Department of Pediatrics,Central Hospital of Shenyang Sujiatun District,Shenyang 110101,China
  • Online:2016-12-25 Published:2018-11-19

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摘要： 目的：观察微生态制剂及胃肠黏膜保护剂治疗小儿抗生素相关性腹泻的疗效。
方法：将160例的儿童抗生素相关性腹泻患儿，按门诊单双号分为对照组和观察组各80例，两组均口服蒙脱石散，观察组在此基础上给予双歧三联活菌片口服，按不同年龄给予不同剂量，两组疗程均为腹泻停止，给药即停止。治疗结束后比较所用退热时间、止泻时间、大便恢复正常时间、临床疗效及不良反应情况。
结果观察组总有效率优于对照组，两组比较差异有统计学意义(P<0.05)。观察组在退热时间、止泻时间、大便恢复正常时间均优于对照组，两组比较差异有统计学意义(P<0.05)。两组治疗后未见不良反应发生。
结论：双歧三联活菌片与蒙脱石散联合应用，效果比单纯使用蒙脱石散好，值得临床推广。

关键词: 抗生素相关性腹泻, 微生态制剂, 胃肠黏膜保护剂, 儿童

Abstract:

Objective:To observe the clinical therapeutic effect of probiotics and gastrointestinal mucosal protective agents on antibiotic-associated diarrhea in children.
Methods:A total of 160 cases of children with antibiotic-associated diarrhea were divided into control group and observation group,each group with 80 cases,according to odd or even number of clinical visits.Both groups were given montmorillonite powder,and the observation group was added Bifid Triple Viable tablets taken orally,the dosage varying with different ages.The treatment stopped when the diarrhea stopped.After treatment,compare the time for fever to recede,the time for diarrhea to stop,the time for bowel movement to return normal,the clinical effect and the adverse reactions between the two groups.
Results:The total effective rate of the observation group was better than that of the control group,the difference being of statistical significant(P<0.05).Concerning the time of the abatement of fever,the time for diarrhea to stop,and the time for bowel movement to return normal,the observation group was better than the control group,and the difference was statistical(P<0.05).No adverse reaction was observed in the two groups.
Conclusion：The effect of Bifid Triple Viable tablets combined with montmorillonite powder is better than that of single use of montmorillonite,and the combination use should be popularized clinically.

Key words: Antibiotic-associated Diarrhea, Probiotics, Protective Agent of Gastrointestinal mucosa, Children