ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (5): 536-538.doi: 10.3969/j.issn.167-3865.2016.05.026

• 临床研究 • 上一篇    下一篇

25-(OH)D3与相关血液微量元素的相关性研究

何毅，钟燕，朱莎，丁大为   

  1. 410007 长沙，湖南省儿童医院儿童保健所
  • 出版日期:2016-10-25 发布日期:2017-12-08
  • 通讯作者: 何毅，E-mail:756668246@qq.com
  • 作者简介:何毅(1978-)，女，主治医师。研究方向：儿童保健工作

Study on the relativity of the the related trace elements in serum with 25-(OH)D3

HE Yi,ZHONG Yan,ZHU Sha,DING Dawei   

  1. Hunan  Children′s Hospital, Changsha 410007,China.
  • Online:2016-10-25 Published:2017-12-08

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摘要：
目的：测定不同年龄段儿童的血清25-羟维生素D3（25-(OH)D3)的含量，并探究25-(OH)D3与骨碱性磷酸酶（BAKP)及微量元素的相关性。
方法：随机选择382例本院儿童保健所门诊正常体检儿童作为研究对象，根据年龄分为≤1岁，＞1～3岁，＞3～5岁，＞5～7岁，＞7～12岁共5组，采用酶联免疫测试法检测血清25-(OH)D3含量，并测定血清BAKP及Cu、Zn、Fe、Mg等微量元素含量，比较25-(OH)D3与BAKP、微量元素的相关性。
结果：各年龄段儿童均明显存在25-(OH)D3缺乏的现象，采用Pearson相关性检验表明，Zn和BAKP、Cu，Fe和BAKP、Cu、Zn，Mg和Cu、Z、Fe之间均存在明显的相关性(P<0.05)；25-(OH)D3与BAKP存在相关性(P<0.05)；而25-(OH)D3与Cu、Zn、Fe、Mg等微量元素之间均无明显相关性(P>0.05)。
结论：0～12岁的儿童均不同程度的缺乏25-(OH)D3，尤其是0～3岁的儿童缺乏25-(OH)D3现象严重。相关性分析说明25-(OH)D3与BAKP存在相关性，与Cu、Zn、Fe、Mg等微量元素无相关性，补充Zn和Fe可有助于改善BAKP含量，对提高儿童身体健康健康具有重要意义。

关键词: 25-(OH)D3, BAKP, 微量元素, 儿童

Abstract:


Objective ：To measure the content of 25-(OH)D3(25-hydroxylase catalytic system generated ossification diol) in the blood serum of the children of different ages, and to probe into the relativity of 25-(OH)D3 with BAKP(bone alkaline phosphatase) and trace elements.
Methods： Totally 382 cases of children were chosen, who took routine physical examination in the health care center of our hospital, as the research object.Divide the children into 5 groups according to their different ages:≤1，＞1～3，＞3～5，＞5～7 and ＞7～12. Detect the concentration of serum 25-(OH)D3, the serum BAKP and some trace elements, such as the Cu,Zn,Fe and Mg by using enzyme-linked immune testing method.
Results： Children of all ages were obviously in lack of 25-(OH)D3.By using the Pearson correlation analysis, it was shown that the relativity between Zn and BAKP,Cu，between Fe and BAKP,Cu,Zn，between Mg and Cu,Z,Fe was very obvious(P<0.05).There was relativity between 25-(OH)D3 and BAKP(P<0.05).But there was no obvious relativity between 25-(OH)D3 and trace elements such as Cu,Zn,Fe and Mg(P>0.05).
Conclusion： Children of 0～12 years old have different degree of 25-(OH)D3 deficiency, which is especially serious in the children of 0～3 years old.The relativity analysis shows that there is connection between 25-(OH)D3 and BAKP, but there is no connection between 25-(OH)D3 and such trace elements as Cu,Zn,Fe and Mg.Taking Zn and Fe can help improve the BAKP content,which is very beneficial to children′s health.

Key words: 25-(OH)D3, BAKP, Trace elements, Child