ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (5): 495-497.doi: 10.3969/j.issn.167-43865.2016.04.011

• 临床研究 • 上一篇    下一篇

新生儿巨细胞病毒感染临床分析

于芳，李彤   

  1. 110014 沈阳，沈阳市妇婴医院儿科
  • 出版日期:2016-10-25 发布日期:2017-12-08
  • 通讯作者: 于芳，E-mail：609185738@qq.com
  • 作者简介:于芳(1973-)，女，副主任医师。研究方向：新生儿疾病的诊治

Clinical analysis of neonates with cytomegalovirus infection

YU Fang，LI Tong   

  1. Department of Paediatrics，Shenyang Woman and Children's Hospital，Shenyang 110014，China.
  • Online:2016-10-25 Published:2017-12-08

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摘要：
目的：分析新生儿巨细胞病毒感染的临床特点及观察更昔洛韦治疗新生儿巨细胞病毒感染的临床效果。
方法：2011年1月至2015年10月沈阳市妇婴医院新生儿科收治住院的HCMV感染新生儿40例。对有多脏器损害者予以注射用更昔洛韦静脉滴注，每次5 mg/kg，12 h 1次，连用14 d，之后予以单剂量7.5 mg/(kg·d)，连用4周。分析其临床特点及疗效。
结果：患儿临床表现多样，可单一或多脏器损害，其中多脏器损害(受累器官达2个或2个以上)29例，占72.5%。其中治愈10例(34.5%)，明显好转13例(44.8%)，好转5例(17.2%)，无效1例(3.5%)。
结论：新生儿巨细胞病毒感染临床表现缺乏特异性，故应加强对育龄妇女的宣教，孕妇产前检查及新生儿筛查，减少先天性巨细胞病毒感染的发生。采用更昔洛韦治疗新生儿巨细胞病毒感染效果满意。

关键词: 巨细胞病毒感染, 多脏器损伤, 更昔洛韦, 婴儿, 新生

Abstract:


Objective ：To study the clinical features of neonates with cytomegalovirus infection, and to observe clinical effect of ganciclovir(GCV) in the treatment of neonatal cytomegalovirus infection.
Methods ：Forty cases of neonates in our hospital with cytomegalovirus infection were collected from January 2011 to October 2015. The patients with multiple organ damage were treated with ganciclovir injection,5 mg/kg per time, once every 12 hours, continuously for 14 days; then 7.5 mg/kg per time，once a day, continuously for 4 weeks. Analyse the clinical features and efficacy.
Results ：The 40 neonates were diverse in clinical manifestations, with single or multiple organ damage. The multiple organ damage accounted for 72.5%. Of them, 10 were healed(34.5%), 13 were clearly better(44.8%),5 were better(17.2%),and 1 had no effect.
Conclusion ：The clinical manifestations of neonates with cytomegalovirus infection are not special. Education for women of childbearing age, prenatal examination and neonatal screening are important measures in preventing neonates with cytomegalovirus infection. The effect of ganciclovir(GCV) in the treatment of neonatal cytomegalovirus infection is satisfactory.

Key words: Cytomegalovirus infection, Multiple organ damage, Ganciclovir, Baby,newborn