ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (5): 480-482.doi: 10.3969/j.issn.167-43865.2016.05.006

• 临床论著 • 上一篇    下一篇

安宫牛黄丸治疗重型手足口病疗效观察

朱庆雄，官文芳，张海平，朱春晖，卢宏昌，李苏宝   

  1. 330006 江西 南昌，江西省儿童医院感染科(朱庆雄，朱春晖，李苏宝)；336000 江西 宜春，宜春职业技术学院(官文芳)；332600 江西 都昌，江西省都昌县妇幼保健院(张海平)；330006 江西 南昌，江西省儿童医院中医科(卢宏昌)
  • 出版日期:2016-10-25 发布日期:2017-12-08
  • 通讯作者: 朱春晖，E-mail:646671993@qq.com
  • 作者简介:朱庆雄(1968-)，男，硕士研究生导师，主任医师。研究方向：小儿感染性疾病
  • 基金资助:
    江西省卫计委中医处立项课题(2012A085)

Therapeutic effect of Angong Niuhuang pills on severe hand-foot-mouth disease

ZHU Qingxiong,GUAN Wenfang,ZHANG Haiping,ZHU Chunhui,LU Hongchang,LI Subao.   

  1. Jiangxi Province Children′s Hospital，Nanchang 330006，China.
  • Online:2016-10-25 Published:2017-12-08

PDF (PC)

135

摘要：
目的：观察安宫牛黄丸治疗重型手足口病的疗效及不良反应。
方法：80例符合纳入标准并自愿参加的重型手足口病患儿进入试验，随机分为观察组及对照组各40例。对照组采用病毒唑、人血免疫球蛋白、降颅压及降温等常规治疗，观察组在常规治疗的基础上加用安宫牛黄丸(北京同仁堂生产)，疗程5 d。本研究对两组病例在总有效率、退热时间、嗜睡消失时间、肌阵挛消失时间及危重症转化率五项指标进行分析。
结果：观察组总有效率90.0%(36/40)高于对照组72.5%(29/40)，差异有统计学意义(P<0.05)。观察组退热时间(44.23±10.57)h短于对照组(56.38±15.83)h，差异有统计学意义(P<0.05)；观察组嗜睡消失时间(51.70±7.01)h短于对照组(60.63±15.11)h，差异有统计学意义(P<0.05)；观察组肌阵挛消失时间(43.43±8.07)h短于对照组(50.85±11.90)h，差异有统计学意义(P<0.05)。
结论：安宫牛黄丸对手足口病重型病例能显著缩短退热时间、嗜睡消失时间、肌阵挛消失时间及降低危重症转化率，无明显不良反应及毒副反应，疗效确切，值得推广。

关键词: 手足口病, 重型, 安宫牛黄丸/治疗应用, 副反应, 儿童

Abstract:


Objective：To observe the effect and side effects of Angong Niuhuang pills on severe hand-foot-mouth disease(HFMD).
Methods：Eighty severe HMFD patients who met the inclusion criterion and volunteered to attend the trial were divided into the observation group and the control group randomly,40 patients in each group.The patients in control group were treated with ribavirin,immunoglobulin and symptomatic treatments such as intracranial pressure lowering treatment and defervescence；Angong Niuhuang pills was given for 5 days on the basis of above treatments to the patients in the observation group.The total effective rate，the defervescence time of body temperature,the time needed for sleepiness and myoclonus to disappear and the conversion rate of critically ill patients were compared and analysed.
Results：The total effective rate of observation group was significantly higher than that of control group(90.0% vs 72.5%，P<0.05);the defervescence time of body temperature in the observation group was(44.23±10.57)h,which was shorter than that in the control group(56.38±15.83)h，the difference being statistically significant(P<0.05).The time needed for sleepiness to disappear in the observation group was(51.70±7.01)h,which was shorter than that in the control group(60.63±15.11)h，the difference being statistically significant(P<0.05).The time needed for myoclonus to disappear in the observation group was(43.43±8.07)h,which was shorter than that in the control group(50.85±11.90)h，the difference being statistically significant(P<0.05).The conversion rate of critically ill patients in the observation group(0%) was lower in observation group than that in the control group(5%).
Conclusion：Treatments with Angong Niuhuang pills in severe HFMD can shorten the defervescence time of body temperature and the time needed for sleepiness and myoclonus to disappear, and reduce the conversion rate of critically ill patients,and it has no intolerable side effects and can be applied to clinical work safely.

Key words: Hand-foot-mouth disease, severe, Angong Niuhuang pills, Therapeutic use, Side effects, Child