ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (5): 525-527.doi: 10.3969/j.issn.167-43865.2016.05.022

• 临床研究 • 上一篇    下一篇

肺炎支原体肺炎合并肺外表现患儿外周血 辅助性T细胞表达水平分析

陈小庚，魏杰淼，闫虹   

  1. 110032 沈阳，沈阳市儿童医院内二科(陈小庚，闫虹)，内五科(魏杰淼)
  • 出版日期:2016-10-25 发布日期:2017-12-08
  • 通讯作者: 陈小庚，E-mail：13889380301@163.com
  • 作者简介:陈小庚(1978-)，女，主治医师。研究方向：小儿感染性肺疾病诊断及治疗

Expression of T helper cells in peripheral blood of children with Mycoplasma pneumonia complicated with extrapulmonary manifestations

CHEN Xiaogeng，WEI Jiemiao，YAN Hong   

  1. The Children Hospital of Shenyang，Shenyang 110032，China.
  • Online:2016-10-25 Published:2017-12-08

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摘要：
目的：分析肺炎支原体肺炎(MPP)合并肺外表现患儿外周血辅助性T细胞表达水平。
方法：选择2015年1月至12月在沈阳市儿童医院门诊就诊或住院治疗的MPP患儿97例，入选对象均在开始治疗前接受了外周血辅助性T细胞(CD3+、CD4+、CD8+、CD4+/CD8+)检测，并与同期体检结论正常儿童(对照组，35例)相同测试结果比较。
结果：MPP组外周血CD3+、CD4+表达强度及CD4+/CD8+比值均明显低于对照组，而CD8+水平则明显高于后者，差异均有统计学意义(P<0.05)。97例MPP患儿中，合并肺外表现者43例(44.33%)，合并肺外表现组外周血CD3+、CD4+水平、CD4+/CD8+比值均明显低于无肺外表现组，而CD8+水平则明显高于后者，差异均有统计学意义(P<0.05)。
结论：MPP患儿存在着明确的外周血辅助性T细胞表达异常，合并肺外表现者变化更为显著。

关键词: 肺炎支原体肺炎, 肺外表现, 辅助性T细胞, 儿童

Abstract:


Objective ：To analyze the expression level of T helper cells in peripheral blood of children with Mycoplasma pneumonia complicated with extrapulmonary manifestations.
Methods： We detected the peripheral T helper cells(CD3+,CD4+,CD8+,CD4+/ CD8+)in the blood of the 97 selected continuous cases of children with Mycoplasma pneumoniae pneumonia before starting treatment,who received treatment in the Children Hospital of Shenyang from Jan.to Dec.2015,and compared with the results of the normal children on the medical conclusions at the same test in the same period(control group,n=35).
Results：The expression intensity of the peripheral CD3+,CD4+, and ratio of CD4+ /CD8+ of the Mycoplasma pneumoniae pneumonia group were significantly lower than the control group,while that of CD8+ was higher (P<0.05～ 0.01).In the 97 children with Mycoplasma pneumoniae pneumonia,43 cases had extrapulmonary manifestations(44.33%), and the CD3+level,the CD4+ level,CD4+ /CD8+ ration in the group with extrapulmonary manifestations were obviously lower than the group without extrapulmonary manifestations,while the CD8+ level was higher than the latter(P<0.05～0.01).
Conclusion： Peripheral blood helper T cells are abnormally expressed in children with Mycoplasma pneumonia;these abnormalities are more obvious in the patients complicated with extrapulmonary manifestations.

Key words: Mycoplasma pneumoniae pneumonia, Extrapulmonary manifestations, T helper cells, Child