ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2012, Vol. 4 ›› Issue (1): 31-37.doi: 10.3969/j.issn.1674-3865.2012.01.012

• 综述 • 上一篇    下一篇

益肾活血药治疗小儿原发性肾病综合征的系统评价

邱彩霞，郑健，黄苏萍   

  1. 350004 福州，福建中医药大学研究生院（邱彩霞）；福建中医药大学附属人民医院儿科（郑健）；350001 福州，《福建中医药大学学报》编辑部（黄苏萍）
  • 出版日期:2012-02-25 发布日期:2019-05-09
  • 通讯作者: 郑健，350004 福州，福建中医药大学附属人民医院儿科。
  • 作者简介:邱彩霞（1988-），女，2006级福建中医药大学七年制中医儿科研究生在读。研究方向：小儿肾病、哮喘的诊断与治疗。
  • 基金资助:
    福建省中医临床研究基地中医专科（专病）主要病种临床诊疗优化方案科研项目计划资助（zlcek 01）

The systematic review on medicine for tonifying kidney and promoting blood flow in the treatment of primary nephrotic syndrome in children

QIU Caixia，ZHENG Jian，HUANG Suping.   

  1. The People`s Hospital of Fujian Province，Fuzhou 350004，China
  • Online:2012-02-25 Published:2019-05-09

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摘要：
目的:评价益肾活血药治疗小儿原发性肾病综合征（NS)的临床疗效和安全性。
方法:运用循证医学Cochrance系统评价方法，检索PubMed、中国知网期刊全文数据库、重庆维普全文期刊数据库、中国生物医学文献数据库、中国博士硕士学位论文全文数据库等，检索时间200001/201107，纳入国内外有关益肾活血药治疗NS的随机对照试验。应用Jadad评分评价纳入文献质量，选择胆固醇、三酰甘油、血栓素B2、6酮前列腺素1a、CD3、CD4、CD8、CD4/CD8、复发率、临床疗效、血浆白蛋白、24 h尿蛋白定量、皮质醇等13项结局指标，运用RevMan 5.0软件进行Meta分析。
结果:共纳入13个随机对照试验，共计725例患儿。Jadad评分均为3分。Meta分析显示，除皮质醇1项指标与对照组比较差异无统计学意义外，其他指标差异均有统计学意义（P<0.05）。西药联合益肾活血中药治疗NS，在一定程度上优于西药治疗，且未见不良反应，安全可靠。
结论:现有证据表明，益肾活血药治疗NS有一定的效果。受纳入研究数量与质量限制，其疗效和安全性期待更多高质量随机双盲对照试验加以证实。

Abstract:
Objective:To assess the curative effect and the security of the medicine for tonifying kidney and promoting blood flow in the treatment of primary nephrotic syndrome in children.
Methods:Through retrieval Cochrane,MEDLINE,CNKI,VIP,CBM and Fulltext data base of Chinese Drs and Lics were searched,and the search time was from Jan 2000 to July 2011.RCTs related medicines for tonifying kidney and promoting blood flow of in primary nephrotic syndrome in children were collected.The literature quality was evaluated by Jadad Score and the data analysis was made by RevMan 5.0 software.Thirteen indexes were selected namely,TC,TG,TXB2,6ketoPGF1a,CD3,CD4,CD8,CD4/CD8,ALB,24 h urine protein,compound F,relapse rate and clinical manifestation.
Results:Thirteen studies were included in the analysis, totally 725 patients.Jadad Scores were all 3 points.Meta analysis showed:except for compound F,the other 12 indexes showed obvious difference from the control group(P<0.05).To some degree,the curative effect of Western medicine combined with the medicine for tonifying kidney and promoting blood flow was better than solitary western medicine,and there was fewer adverse reactions,so it`s safe and reliable.
Conclusions:Present evidence shows that the medicine drug for tonifying kidney and promoting blood flow has effect on curing primary nephrotic syndrome in children.Limited by quantity and quality of the literature searched,its curative effect and safety need more highquailty RCT experiments.

Key words: Primary nephrotic syndrome/Tonify kidney and promote blood flow/Systematic review, Meta analysis/RCT/Relapse rate/Child