ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2014, Vol. 6 ›› Issue (3): 221-224.doi: 10.3969/j.issn.1674-3865.2014.03.012

• 临床论著 • 上一篇    下一篇

高胆红素血症对新生儿血清神经元特异性烯醇化酶及神经行为的影响

郭春艳   

  1. 110011 沈阳，沈阳市妇婴医院新生儿科
  • 出版日期:2014-06-25 发布日期:2018-11-19
  • 作者简介:郭春艳（1969-），女，副主任医师。研究方向：新生儿疾病的诊断与治疗。

The effect of hyperbilirubinemia on serum neuron-specific enolase(NSE) and neurological behavior in the neonates

GUO Chun-yan.   

  1. Department of Neonatology,Shenyang Woman and Children's Hospital,Shenyang 110011,China.
  • Online:2014-06-25 Published:2018-11-19

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摘要：
目的：观察高胆红素血症新生儿血清神经元特异性烯醇化酶(NSE)、血清总胆红素（TSB）和新生儿神经行为间的相互影响及临床意义。
方法：86例轻中度高胆血红素血症患儿作为观察组，86例正常足月新生儿为对照组。两组在正常喂养的基础上，观察组给予茵栀黄口服液治疗，并根据黄疸程度给予蓝光照射、新生儿抚触、婴儿游泳、运动训练等；对照组仅给予常规的抚触及游泳、运动等。应用酶联免疫吸附法检测新生儿血清中NSE、TSB含量，并行神经行为能力测定（NBNA）评分。
结果：观察组血清NSE、TSB含量均较对照组显著升高，差异有统计学意义(P<0.05），治疗后两项指标明显下降，观察组NBNA评分值均明显低于对照组，差异有统计学意义(P<0.05)，治疗后组间增高并接近正常值。血清NSE与NBNA评分呈负相关，与TSB呈正相关。
结论：高胆红素血症新生儿血清中NSE明显高于正常新生儿，可作为早期预测新生儿胆红素脑损伤风险的敏感指标，轻中度高胆红素血症对新生儿神经行为有一定影响。

关键词: 高胆红素血症, 黄疸, 治疗, 神经元特异性烯醇化酶, 婴儿, 新生

Abstract:
Objective:To investigate the relationship among serum neuron-specific enolase(NSE),total serum bilirubin and neurological behavior in neonates with hyperbilirubinemia.
Methods:A total of 86 cases of newborn hyperbilirubinemia were included in the boservation group,while 86 normal term newborns were choose as the control group.Enzymelinked immunosorbent assay was used to determine serum concentration of NSE and total serum bilirubin.NBNA score was also determined.
Results:The serum concentrations of NSE and TSB in the observation group were significantly higher than those in the control group(P<0.01);two indicators decreased significantly after treatment.NBNA scores were significantly lower than the control group(P<0.01);After treatment they increased and were close to normal.NSE serum concentration and NBNA score showed a significant negative correlation(P<0.01)，but it was positively correlated with the TSB concentration.
Conclusion: Serum NSE is significantly higher in the hyperbilirubinemia neonates than in the normal ones,which can be an indicator for early prediction of neonatal bilirubin brain injury; Hyperbilirubinemia has some influence on neonatal neurobehavior.

Key words: hyperbilirubinemia, jaundice/treatment, serum neuron specific enolase, infant,newborn