ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (1): 49-52.doi: 10.3969/j.issn.1674-3865.2016.01.019

• 临床研究 • 上一篇    下一篇

尿微量白蛋白、血β2微球蛋白、α1微球蛋白、胱抑素C在小儿感染性肾早期损害的临床意义

郭小梅，徐前，刘燕如，刘春丽   

  1. 014040 内蒙古 包头，包头市第八医院儿科(郭小梅，刘燕如，刘春丽)，检验科(徐前)
  • 出版日期:2016-02-25 上线日期:2018-11-19
  • 通讯作者: 郭小梅，E-mail：gxm7459@126.com
  • 作者简介:郭小梅(1975-)，女，副主任医师。研究方向：小儿内科疾病的诊断与治疗

Clinical significance of urine MA，blood beta2-MG，alpha1-MG，Cys-C in pediatric early renal damageGUO Xiaomei，XU Qian，LIU Yanru，LIU Chunli

GUO Xiaomei，XU Qian，LIU Yanru，LIU Chunli   

  1. Pediatric Department of Baotou Eighth Hospital，Baotou 014040，China
  • Published:2016-02-25 Online:2018-11-19

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258

摘要：
目的：探讨尿微量白蛋白(MA)、血β2微球蛋白(β2-MG)、α1微球蛋白(α1-MG)、胱抑素C(Cys-C)在小儿感染性肾早期损害的临床意义。
方法：包头市第八医院儿科2014年11月至2015年10月收治住院的急性感染患儿500例，通过检测尿MA、血β2-MG、α1-MG、Cys-C、尿素氮(BUN)、肌酐(Cr)，选出尿MA、血β2-MG、α1-MG、Cys-C任一项超出正常参考值者作为肾早损研究对象，为观察组(108例)。同期选择门诊健康体检儿童70例为对照组。观察组以病原体培养、血常规、C反应蛋白、血清降钙素原、血清特异性抗体检查结合临床表现作为病原体诊断依据，确定其感染类型。统计肾早损观察组各指标异常检出率。
结果：观察组中尿MA、血β2-MG、α1-MG、Cys-C水平均高于对照组，差异有统计学意义(P＜0.05)；BUN、Cr与对照组比较差异无统计学意义(P＞0.05)。血α1-MG在各感染组异常检出率最低；病毒感染组尿MA、血β2-MG、Cys-C异常检出率不同，差异有统计学意义(P＜0.05)，其中血β2-MG异常检出率最高；Cys-C在各种类型感染组中异常检出率比较差异无统计学意义(P＞0.05)。
结论：血β2-MG诊断病毒感染性肾早期损害的敏感性最高，Cys-C的增高不受感染类型的限制，是各种类型感染性肾损害的良好诊断指标。

关键词: 肾早期损害, 感染性, 尿微量白蛋白, β2微球蛋白, α1微球蛋白, 胱抑素C, 儿童

Abstract:
Objective：To explore the clinical significance of urine MA，blood beta2-MG，alpha1-MG，Cys-C in pediatric early renal damage.
Methods：Totally 500 cases of children with acute infection in Pediatrics Department of Baotou Eighth Hospital from November 2014 to October 2015 were included. Urine MA，blood beta2-MG，alpha1-MG，Cys-C，BUN，and Cr were detected.Those with increase in any one item were selected as kidney dysfunction observation group(108 cases).At the same time 70 healthy pediatric patients who came for regular check-ups at the OPD were selected as control group.Explore the clinical significance of urine MA，blood beta2MG，alpha1-MG，and Cys-C in different types of infectious early renal damage.
Results：In observation group，urine MA，blood beta2-MG，alpha1-MG and Cys-C were all significantly higher than that of control group(P＜0.05)；BUN and Cr had no statistically significant difference between the two groups(P＞0.05).Blood alpha 1-MG in the infection group had the lowest detection rate. In virus infection group，the detection rate of urine MA，blood beta2-MG and Cys-C was different，the difference being statistically significant(P＜0.05)，in which the detection rate of blood beta2-MG was the highest. Cys-C's detection rate had no statistical difference in different infection groups.
ConclusionThis study suggests the blood beta2-MG is the most sensitive in diagnosis of virus infection with early renal damage.The increase of Cys-C is not limited by the type of infection，and is a good indicator of various types of infectious renal impairment.

Key words: Early renal damage, Infectious, Urine MA, Beta2-MG, Alpha1-MG, Cys-C, Children