ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (1): 52-55.doi: 10.3969/j.issn.1674-3865.2016.01.020

• 临床研究 • 上一篇    下一篇

食物特异性IgG抗体检测在小儿反复呼吸道感染疾病中的应用价值

廖素雯，李柏，梁莹，廖必才   

  1. 530001 南宁，广西壮族自治区民族医院（广西医科大学附属民族医院）儿科
  • 出版日期:2016-02-25 发布日期:2018-11-19
  • 通讯作者: 廖素雯，E-mail：23205822@qq.com
  • 作者简介:廖素雯（1982-），女，医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治

Application value of food specific IgG antibody detection in children with recurrent respiratory tract infections

LIAO Suwen，LI Bai，LIANG Ying，LIAO Bicai   

  1. Pediatric Department of the Guangxi Zhuang Autonomous Region National Hospital，Nanning 530001，China
  • Online:2016-02-25 Published:2018-11-19

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摘要：
目的：观察食物特异性IgG抗体检测在儿童反复呼吸道感染疾病中的应用价值。
方法：广西壮族自治区民族医院儿科2014年4月至2015年4月收治反复呼吸道感染患儿200例，同期选取本院健康体检的正常儿童100例作为对照组。采用酶联免疫方法检测人血清中的14种食物（牛肉、鸡肉、鱼、玉米、蟹、蛋清/蛋黄、蘑菇、牛奶、猪肉、大米、虾、大豆、西红柿、小麦）特异性IgG抗体。观察两组患儿14种食物特异性IgG阳性率，并分年龄段比较食物特异性IgG阳性率；两组患儿对食物过敏IgG检测，并分年龄段比较过敏食物的阳性率；两组IgG阳性患儿中IgE及嗜酸性粒细胞阳性率。
结果：观察组儿童食物血清特异性IgG抗体检测阳性率为76.0%（152/200）,显著高于对照组26.0%(26/100)，差异有统计学意义（χ2=69.07，P＜0.05）。观察组0～2岁、＞2～5岁、＞5～14岁不同年龄段食物血清特异性IgG抗体检测阳性率均显著高于对照组，差异有统计学意义（P＜0.05）。观察组患儿14种食物过敏IgG阳性率较高的食物分别是鸡蛋、牛奶、螃蟹，对照组分别是鸡蛋、螃蟹、鱼；观察组鸡蛋、牛奶、虾、大豆IgG阳性率均高于对照组，差异有统计学意义（P＜0.05）。观察组0～2岁患儿牛奶IgG阳性率明显高于对照组，差异有统计学意义（P＜0.01）；观察组＞2～5岁患儿鸡蛋、牛奶IgG阳性率明显高于对照组，差异有统计学意义（P＜0.01）；观察组＞5～14岁患儿鸡蛋、海产品IgG阳性率明显高于对照组，差异有统计学意义（P＜0.01）。两组IgG阳性患儿中IgE及嗜酸性粒细胞阳性结果比较差异无统计学意义（P＞0.05）。
结论：食物特异性在反复呼吸道感染患儿中有较高的阳性率，应根据食物特异性抗体对患儿进行治疗。

关键词: 反复呼吸道感染, 食物不耐受, 食物特异性, 儿童

Abstract:
Objective：To investigate the application value of food specific IgG antibody detection in children with recurrent respiratory tract infections.
Methods：From April 2014 to April 2015，200 patients with recurrent respiratory tract infection in our hospital were selected as observation group，and 100 cases in our hospital were selected as the control group;the two groups of children were observed for 14 kinds of food specific IgG positive rate，IgE and the positive rate of eosinophils.
Results：The positive rate of serum specific IgG antibody in the observation group was 76%，significantly higher than that of the control group(26%)，the difference being statistically significant(P＜0.05).The positive rates of serum specific IgG antibodies in different age groups，such as 0 to 2 years，5 to 6 years old，3 to 14 years old，were significantly higher than those in the control group，the difference being statistically significant(P＜0.01).The higher positive rates of 14 kinds of food allergic IgG in the observation group were shown in egg，milk and crab，and the positive rate of IgG in the control group were shown in egg，crab and the fish;the positive rates of IgG in egg，milk，shrimp and soybean in the observation group were higher than those in the control group(P＜0.05).The positive rate of IgG in milk in children aged 0 to 2 years old in observation group was significantly higher than that in control group(P＜0.01).The positive rate of IgG in children aged 3 to 5 years old in observation group was significantly higher than that in control group(P＜0.01).The positive rate of seafood IgG in children aged 6 to 14 years old in the observation group was significantly higher than that in the control group(P＜0.01).There was no significant difference in the positive results of IgE and eosinophils between the two groups in IgG positive children(P＞0.05).
Conclusion：Food specificity has a high positive rate in recurrent respiratory tract infections，and the treatment for children should be based on the specific antibody of food.

Key words: Recurrent respiratory tract infections, Food intolerance, Food specificity, Children