ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (2): 177-179.doi: 10.3969/j.issn.1674-3865.2016.02.017

• 临床研究 • 上一篇    下一篇

血清乳酸清除率和降钙素原在小儿脓毒性休克检测中的临床意义

常久利   

  1. 274000 山东 菏泽，菏泽市立医院儿科
  • 出版日期:2016-04-25 发布日期:2018-11-19
  • 作者简介:常久利(1969-)，女，医学硕士，副主任医师。研究方向：小儿内分泌系统疾病的诊治，E-mail:chjl69@126.com

Clinical significance of the serum lactate clearance rate and calcitonin in pediatric septic shock

CHANG Jiuli   

  1. Department of Pediatrics,Heze Municipal Hospital,Heze 274000,China.
  • Online:2016-04-25 Published:2018-11-19

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摘要：
目的：探讨血清乳酸清除率和降钙素原在小儿脓毒性休克检测中的临床意义。
方法：2014年1月至2015年5月菏泽市立医院小儿重症监护病房收治脓毒性休克患儿44例，根据患儿病情分为非危重组28例和危重组16例；根据患儿不同预后分为存活组34例和死亡组10例。对两组血清乳酸清除率和降钙素原进行比较，并对二者进行相关性分析。
结果：非危重组血清乳酸清除率显著高于危重组，差异有统计学意义(P<005)；非危重组的降钙素原水平显著低于危重组，差异有统计学意义(P<005);死亡组的乳酸清除率显著低于存活组，差异有统计学意义(P<005)；死亡组降钙素原水平显著高于存活组，差异有统计学意义(P<005)；血清乳酸清除率及降钙素原呈负相关(P<005)。
结论：监测血清乳酸清除率和降钙素原的水平具有重要的临床意义，可作为预测小儿脓毒性休克患儿预后的重要指标之一。

关键词: 脓毒性休克, 血清乳酸清除率, 降钙素, 预后, 儿童

Abstract:
Objective:To explore clinical significance of the serum lactate clearance rate and calcitonin in pediatric septic shock.
Methods:Totally 44 cases of septic shock patients were selected from January 2014 to May 2015 as the research object in pediatric intensive care units of our hospital.According to the disease situation they were divided into non-critical group and critical group;according to the different outcomes of patients,they were divided into survival group(34 cases)and death group(10 cases).The serum lactate clearance rate and calcitonin of two groups were compared,and their correlation was analyzed.
Results:Serum lactate clearance rate of non-critical group was obviously higher than that of critical group,the difference being statistically significant(P<005);calcitonin level of non-critical group was significantly lower than that of critical group,the difference being statistically significant(P<005);lactate clearance rate of death group was obviously lower than that of the survival group，the difference being statistically significant(P<005);the level of calcitonin of death group was obviously higher than that of the survival group,the difference being statistically significant(P<005);serum lactate clearance rate and calcitonin showed a negative correlation(P<005).
Conclusion:It has important clinical significance to monitor the levels of serum lactate clearance rate and calcitonin,which can be used as the important indicator of the prognosis in pediatric septic shock.

Key words: Septic shock, Serum lactate clearance rate, Calcitonin, Prognosis, Children