ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (2): 180-182.doi: 10.3969/j.issn.1674-3865.2016.02.018

• 临床研究 • 上一篇    下一篇

红霉素和阿奇霉素序贯治疗小儿肺炎支原体肺炎的疗效观察

江星，何柳芳   

  1. 518000 广东 深圳，深圳市南山区西丽人民医院儿科(江星)；深圳市儿童医院新生儿科(何柳芳)
  • 出版日期:2016-04-25 发布日期:2018-11-19
  • 通讯作者: 江星，E-mail：xukail0102@163.com
  • 作者简介:江星(1983-)，女，医学硕士，主治医师。研究方向：小儿内科疾病的诊断与治疗。
  • 基金资助:
    国家自然科学基金资助项目(81300529)

Clinical effect of sequential therapy with erythromycin and azithromycin in the treatment of children with mycoplasmal pneumonia

JIANG Xing，HE Liufang   

  1. Xili People′s Hospital,Shenzhen 518000,China.
  • Online:2016-04-25 Published:2018-11-19

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摘要：
目的：观察阿奇霉素序贯疗法与红霉素序贯疗法对小儿肺炎支原体肺炎的疗效。
方法：2013年4月至2015年3月深圳市南山区西丽人民医院儿科收治小儿肺炎支原体肺炎患儿48例，随机分为对照组和观察组各24例。对照组采用红霉素序贯疗法，观察组采用阿奇霉素序贯疗法，对两组患儿治疗后疗效及安全性进行分析。
结果：观察组治疗后总有效率为9167%（22/24），明显高于对照组6667%（16/24），差异有统计学意义(P<005)；治疗后不良反应发生率比较，观察组不良反应发生率为833%（2/24），对照组为3333%（8/24），差异有统计学意义(P<005)。
结论：小儿肺炎支原体肺炎采用阿奇霉素序贯疗法治疗的效果显著，且安全性高。

关键词: 肺炎支原体肺炎, 阿奇霉素, 红霉素, 儿童

Abstract:
Objective:To discuss the clinical effect of sequential therapy with erythromycin and azithromycin in the treatment of children with mycoplasmal pneumonia.
Methods:From Apr.2013 to Mar.2015,a total of 48 mycoplasmal pneumonia children who accepted treatments in our hospital were taken as the clinical research objects,and these patients were randomly divided into control group(24 cases)and observation group(24 cases).Patients in the control group accepted erythromycin sequential therapy;the other patients in the observation group accepted azithromycin sequential therapy.After treatment,we compared and analyzed their clinical efficacy and safety.
Results:The total effective rate of the observation group was 9167%,which was significantly higher than that of the control group(6667%),and the difference between these two groups was statistically significant(P<005);the adverse reaction rate of the observation group was 833%,which was significantly lower than that of the control group(3333%),and the difference between these two groups was statistically significant(P<005).
Conclusion:Azithromycin sequential therapy,which has the advantage of high safety,is a useful approach to the children with mycoplasmal pneumonia.

Key words: Mycoplasmal pneumonia, Azithromycin, Erythromycin, Children