ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (2): 190-192.doi: 10.3969/j.issn.1674-3865.2016.02.022

• 临床研究 • 上一篇    下一篇

Insure技术治疗新生儿呼吸窘迫综合征的临床疗效

张晓婷，庞英超，陈裕萍   

  1. 518103 广东 深圳，深圳市宝安区福永人民医院新生儿科
  • 出版日期:2016-04-25 发布日期:2018-11-19
  • 通讯作者: 庞英超，E-mail：pangyingchao@126.com
  • 作者简介:张晓婷(1983-)，主治医师。研究方向：新生儿疾病的诊治

Clinical effect of Insure technique in the treatment of neonatal respiratory distress syndrome

ZHANG Xiaoting，PANG Yingchao，CHEN Yuping   

  1. Department of Pediatrics,Fuyong People′s Hospital of Baoan District,Shenzhen 518103,China.
  • Online:2016-04-25 Published:2018-11-19

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摘要：
目的：观察Insure技术治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。
方法：2010年1月至2011年12月深圳市宝安区福永人民医院新生儿科收治NRDS患儿36例为对照组，2012年1月至2013年12月收治NRDS患儿42例为观察组。观察组采用Insure技术进行抢救治疗；对照组采用给予肺泡表面活性物质(PS)后持续有创正压通气治疗。观察两组治疗前后动脉血气变化情况、相关并发症的发生率、呼吸机使用时间及胸部X线改善情况。
结果：两组治疗后5、10 h PaO2较治疗前显著升高，PaCO2显著降低，差异均有统计学意义(P<005)。治疗前及治疗后5、10 h两组患儿的PaO2、PaCO2比较差异均无统计学意义(P>005)。观察组新生儿出现肺气漏、呼吸机相关性肺炎的发生率分别为238%(1/42)，952%(4/42)，均低于对照组1667%(6/36)，2778%(10/36)，差异无统计学意义(P>005)。观察组患儿呼吸机上机时长为(329±108)d，显著短于对照组(545±089)d，两组比较差异有统计学意义(P<005)。观察组治疗12 h肺野透亮度改善率为905%(38/42)，对照组为917%(33/36)，两组比较差异无统计学意义(P>005)。
结论：采用Insure技术治疗NRDS疗效满意，可减少呼吸机使用时长及相关并发症的发生。

关键词: NRDS, Insure技术, 临床疗效, 儿童

Abstract:
Objective:To observe the clinical effect of Insure technique in the treatment of neonatal respiratory distress syndrome(NRDS).
Methods:From January 2010 to December 2011,36 children with NRDS who were treated in Neonatal Department of Fuyong People′s Hospital of Baoan District were included as control group,and 42 cases of NRDS who were treated from January 2012 to December 2013 were included as the observation group.The control group was given continuous invasive positive pressure ventilation in the treatment after administration of pulmonary surfactant;the observation group was treated with Insure technology for salvage therapy.Observe the blood gas changes of two groups before and after treatment,the incidence of related complications,time of use of breathing machine and chest X-ray improvement.
Results:At 5 h and 10 h after treatment,PaO2 increased significantly than before in both groups,while PaCO2 was significantly reduced(P<005).Before treatment and 5 h and 10 h after treatment,PaO2 and PaCO2 had no statistically significant difference between the two groups(P>005).In observation group incidence rate of air leak and ventilator-associated pneumonia was 238%(1/42)and 952%(4/42),which was lower than control group［1667%(6/36),2778%(10/36)］respectively,the difference being not statistically significant(P>005).In the observation group,the length of ventilation on the machine was(329±108)d,significantly shorter than the control group(545±089)d,the difference being statistically significant(P<005).The improvement rate of 12 h lung field transparency in the observation group was 905%(38/42),while in the control group it was 917%(33/36),the difference being not statistically significant(P>005).
Conclusion:Insure technique is used to treat NRDS with satisfactory curative effect,which can reduce the duration of ventilator use and the occurrence of related complications.

Key words: NRDS, Insure technology, Clinical efficacy, Children