ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (3): 253-256.doi: 10.3969/j.issn.1674-3865.2016.03.002

• 性早熟专栏 • 上一篇    下一篇

RFRP-3/GPR147信号通路在哺乳动物生殖系统中作用的研究进展

韩兴绘，俞建   

  1. 201102上海，复旦大学研究生学院(韩兴绘)|复旦大学附属儿科医院中医科(俞建)
  • 出版日期:2016-06-25 发布日期:2018-11-19
  • 通讯作者: 俞建，E-mail：yuj@shmu.edu.cn
  • 作者简介:韩兴绘(1989-)，女，复旦大学2013级硕士研究生在读。研究方向：中西医结合治疗儿科疾病及相关机制研究

Research progress of regulatory effects of RFRP-3/GPR147 signaling pathway on mammalian reproductive system

HAN Xinghui，YU Jian   

  1. Department of Integrative Medicine，Children's Hospital of Fudan University，Shanghai 201102，China.
  • Online:2016-06-25 Published:2018-11-19

PDF (PC)

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摘要：
哺乳动物生殖系统的各项功能依赖于下丘脑-垂体-性腺(HPG)轴的调控，是多种因子参与的复杂的生物学过程。RFRP-3是目前下丘脑中唯一已知的HPG轴抑制因子。近年来大量研究发现，RFRP-3能与其受体GPR147结合，抑制促性腺激素释放激素、促黄体生成素的合成与分泌，进而影响生殖系统的功能。本文总结近十年有关哺乳动物RFRP-3/GPR147信号通路的研究，并系统阐述RFRP-3 对 HPG 轴的可能调控机制以及其在生殖系统中的作用。

关键词: 性发育, RFRP-3, GnRH, LH, 生殖系统

Abstract:
The function of mammalian reproductive system，a complex biological process involving multiple regulators, depends on the regulation of hypothalamic-pituitary-gonad axis. At present, RFRP-3 is the only one inhibitor of HPG axis known at the hypothalamic level in mammals. In recent years, a large number of studies have found that RFRP-3 can inhibit GnRH and LH release in mammals by combining into the G protein coupled receptor 147(GPR147) and affect the function of reproductive system. In this review, the authors summarize the significant research advances in RFRP/GPR147 signaling pathway in mammalian species in the recent ten years. In addition, the regulatory mechanism of RFRP-3 in HPG axis and role of RFRP-3 in modulating mammalian reproductive system are systematically elaborated.

Key words: Puberty onset, RFRP-3, GnRH, LH, Reproductive system