ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (4): 420-422.doi: 10.3969/j.issn.1674-3865.2016.04.016

• 临床研究 • 上一篇    下一篇

匹多莫德口服液治疗小儿反复呼吸道感染疗效观察

刘传俊   

  1. 457600 河南 濮阳，河南省台前县人民医院儿科
  • 出版日期:2016-08-25 发布日期:2018-11-19
  • 作者简介:刘传俊(1973-)，男，主治医师。研究方向：小儿呼吸系统疾病的诊治，E-mail：838459390@qq.com

Clinical effect observation on Pidotimod solution in the treatment of children with recurrent respiratory infection

 LIU Chuanjun   

  1. Pediatric Department, People's Hospital of Taiqian County, Puyang 457600, China.
  • Online:2016-08-25 Published:2018-11-19

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摘要：
目的：观察匹多莫德口服液治疗小儿反复呼吸道感染的临床疗效。
方法：2014年5月至2015年5月河南省台前县人民医院儿科收治住院的小儿反复呼吸道感染患者80例，随机分为对照组和观察组各40例。两组均给予常规治疗，观察组加用匹多莫德口服液，连续给药4周。检测血清白细胞介素6、γ干扰素、白细胞介素10水平；同时检测血清免疫球蛋白(IgA、IgG、IgE)水平；观察两组疗效及治疗1个月内感染次数、抗生素使用时间及感染消失时间情况。
结果：治疗后观察组总有效率为95.0%(38/40)，显著高于对照组77.5%(31/40)，差异有统计学意义(P<0.05)。治疗后观察组白细胞介素6、白细胞介素10水平显著低于对照组，γ干扰素显著高于对照组，差异有统计学意义(P<0.05)。治疗后观察组IgA、IgG水平显著高于对照组，IgE水平显著低于对照组，差异有统计学意义(P<0.05)。观察组感染消失时间、感染次数、抗生素使用时间明显少于对照组，差异有统计学意义(P<0.05)。
结论：小儿反复呼吸道感染采用匹多莫德治疗，疗效显著，具有推广价值

关键词: 反复呼吸道感染, 匹多莫德, 疗效, 儿童

Abstract:


Objective：To study the clinical effect of Pidotimod solution in the treatment of children with recurrent respiratory infection.
Methods：Totally 80 children with recurrent respiratory infection treated from May 2014 to May 2015 in our hospital were selected. The patients were equally divided into control group and test group. Both groups received the conventional therapy. The test group was also given Pidotimod solution. The curative effect of two groups was observed.
Results：The curative effect of test group was better than control group(P＜0.05). After treatment, the level of IL-6 and IL-10 in test group was much lower, while the level of IFN-γ of test group was much higher(P＜0.05). After treatment, the level of IgE of test group was much lower, while the level of IgA and IgG of test group was much higher(P＜0.05).The time for infection to disappear, the infection frequency and the duration of antibiotic use were much shorter in the test group(P<0.05).
Conclusion：Pidotimod solution has an obvious effect on children with recurrent respiratory infection. It is worthy of promotion.

Key words: Recurrent respiratory infection, Pidotimod, Curative effect, Children