ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 602-604.doi: 10.3969/j.issn.1674-3865.2016.06.017

• 临床研究 • 上一篇    下一篇

降钙素原、超敏C反应蛋白及白细胞联合检测在新生儿败血症早期诊断中的应用价值

冯改梅   

  1. 456750 河南 鹤壁，河南省淇县人民医院儿科
  • 出版日期:2016-12-25 发布日期:2018-11-19
  • 作者简介:冯改梅(1979-)，女，副主任医师。研究方向：新生儿疾病的诊断与治疗，E-mail：qxryfgm@163.com

Application value of combined detection PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis

FENG Gaimei   

  1. Qixian People's Hospital of Henan,Hebi 456750,China
  • Online:2016-12-25 Published:2018-11-19

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摘要： 目的：探讨降钙素原（PCT）、超敏C反应蛋白（hs-CRP）及白细胞（WBC）联合检测在新生儿败血症早期诊断中的应用。
方法：选取2013年1月至2016年1月确诊新生儿败血症患儿68例为观察组，同期健康新生儿68例为对照组，采用酶联荧光分析技术测定PCT，免疫比浊法测定hs-CRP，Sysmex 800血液分析仪分析WBC。
结果：治疗前观察组PCT、hs-CRP及WBC值明显高于对照组，差异有统计学意义(P<0.05)，治疗后观察组PCT、hs-CRP及WBC值明显降低，与治疗前比较差异有统计学意义(P<0.05)；PCT、hs-CRP及WBC三项联合检测用于诊断的特异性、阳性预测值及阴性预测值均高于任意两项联合检测。
结论：PCT、hs-CRP及WBC联合检测可用于新生儿败血症早期诊断，有助于提高诊断准确率。

关键词: 新生儿败血症, PCT, hs-CRP, WBC

Abstract: Objective:To study the application of combined detection of PCT,hs-CRP and WBC in the early diagnosis of neonatal sepsis.
Methods:A total of 68 neonates diagnosed with sepsis from Jan. 2013 to Jan. 2016 were chosen as the observation group, and 68 healthy neonates in the same period were included as the control group. Enzyme-linked fluorescence analysis was used to detect PCT, immuno turbidimetry was used to detect hs-CRP and Sysmex 800 blood analyzer was used to analyze WBC.
Results:The value of PCT,hs-CRP and WBC was remarkably higher in the observation group than in the control group before treatment(P<0.05), but after treatment, these values significantly decreased in observation group, and there was statistical difference compared with those before treatment(P<0.05). The combined detection of PCT,hs-CRP and WBC was higher in specificity of diagnosis, positive prediction value and negative prediction value when compared with the combined detection of any two items.
Conclusion：The combined detection of PCT, hs-CRP and WBC can be used in the early diagnosis of neonatal sepsis, which helps to improve the diagnosis accuracy.

Key words: Neonatal sepsis, PCT, hs-CRP, WBC