孟鲁司特钠对婴幼儿喘息的早期干预及预防哮喘发生的临床研究

doi:10.3969/j.issn.1674-3865.2016.06.024

中国中西医结合儿科学 ›› 2016, Vol. 8 ›› Issue (6): 622-625.doi: 10.3969/j.issn.1674-3865.2016.06.024

孟鲁司特钠对婴幼儿喘息的早期干预及预防哮喘发生的临床研究

臧亚勤，徐亮，沈耀红

215008 江苏苏州，苏州市立医院北区儿科(臧亚勤，沈耀红)，东区儿科(徐亮)

出版日期:2016-12-25 发布日期:2018-11-19
通讯作者: 徐亮，E-mail：13656212716@163.com
作者简介:臧亚勤(1975-)，女，副主任医师。研究方向：小儿用药

Clinical study of Montelukast early intervention on severity of wheezing in infants and prevention of the development of asthma

ZANG Yaqin，XU Liang，SHEN Yaohong

North of Pediatrics，Suzhou City Hospital,Suzhou 215008,China

Online:2016-12-25 Published:2018-11-19

摘要/Abstract

摘要： 目的：观察孟鲁司特钠咀嚼片早期干预治疗对婴幼儿喘息发作的治疗效果以及喘息后哮喘等影响。
方法：2013年1月至2015年1月苏州市立医院儿科收治住院的婴幼儿喘息患儿96例，随机分成观察组和对照组各48例。对照组给予常规综合治疗，观察组在对照组治疗基础上给予孟鲁司特钠咀嚼片，观察短期疗效、临床症状评分，随访1年半内的哮喘发生率。
结果：观察组总有效率为93.75%(45/48)，显著高于对照组79.17%(38/48)，差异有统计学意义(P<0.05)。治疗后观察组患儿喘息、咳嗽、哮鸣音以及痰鸣音评分显著低于对照组，差异有统计学意义(P<0.05)。观察组1年半内喘息发作次数明显少于对照组，平均每次持续时间也显著短于对照组，差异有统计学意义(P<0.05)；随访1年半，观察组哮喘发生率为8.33%(4/48)，明显低于对照组22.92%(11/48)，差异有统计学意义(P<0.05)。两组患儿均无明显的不良反应发生。
结论：孟鲁司特钠咀嚼片早期干预治疗提高了治疗效果，缓解了急性发作期临床症状，降低了喘息后哮喘的发生率。

关键词: 婴幼儿喘息, 哮喘, 孟鲁司特钠咀嚼片, 短期疗效

Abstract: Objective:To study the effect of Montelukast early intervention in wheezing of infants and in the prevention of asthma.
Methods:Between January 2013 and January 2015, 96 pediatric patients with wheezing were admitted to the Suzhou Municipal Hospital, and they were divided randomly into observation group and control group, each with 48 cases. The control group was treated with conventional therapy, while Montelukast sodium chewable tablets were given in observation group on the basis of treatment for control group. Observe the short-term effect and the clinical symptom score, and the incidence of asthma was followed up for 1.5 years.
Results:The total short-term rate was 93.75% in observation group and which was significantly higher than that of control group(79.17%), the difference being significant(P<0.05). After treatment, symptom scores for observation group significantly reduced, which were significantly lower than the control group, the difference being significant(P<0.05). Wheezing episodes for the observation group were significantly fewer than the control group, and the average duration was significantly shorter than the control group within 1 and a half years, the difference being significant(P<0.05). After 1 and a half years of follow-up, the incidence of asthma in the observation group was significantly lower than the control group, the difference being significant(P<0.05). No obvious adverse reaction occurred in both groups.
Conclusion：Montelukast early intervention can improve outcomes, alleviate clinical symptoms of acute exacerbation and reduce the incidence of asthma after wheezing.

Key words: Infant wheezing, Asthma, Montelakast sodium chewable tablets, Short-term effect

臧亚勤，徐亮，沈耀红. 孟鲁司特钠对婴幼儿喘息的早期干预及预防哮喘发生的临床研究[J]. 中国中西医结合儿科学, 2016, 8(6): 622-625.

ZANG Yaqin，XU Liang，SHEN Yaohong. Clinical study of Montelukast early intervention on severity of wheezing in infants and prevention of the development of asthma[J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2016, 8(6): 622-625.

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孟鲁司特钠对婴幼儿喘息的早期干预及预防哮喘发生的临床研究

Clinical study of Montelukast early intervention on severity of wheezing in infants and prevention of the development of asthma

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