ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (2): 144-146.doi: 10.3969/j.issn.1674-3865.2017.02.017

• 临床研究 • 上一篇    下一篇

槐杞黄颗粒治疗呼吸道合胞病毒毛细支气管炎疗效观察

王洪峰   

  1. 154002 黑龙江 佳木斯，佳木斯市中心医院儿科
  • 出版日期:2017-04-25 发布日期:2017-12-18
  • 作者简介:王洪峰(1981-)，男，医学硕士，主治医师。研究方向：小儿呼吸系统疾病的诊治，E-mail:w27421973@163.com

Clinical observation on treatment for respiratory syncytial virus bronchiolitis with Huaiqihuang granule

WANG Hongfeng   

  1. Pediatric Department, Jiamusi Central Hospital, Jiamusi 154002,China
  • Online:2017-04-25 Published:2017-12-18

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摘要：
目的：观察槐杞黄颗粒治疗呼吸道合胞病毒(RSV)毛细支气管炎患儿的临床效果。
方法：2014年5月至2016年2月佳木斯市中心医院儿科收治住院的RSV毛细支气管炎患儿70例，随机分为观察组和对照组各35例。对照组采用吸氧、止咳、平喘、化痰等常规治疗，观察组在对照组治疗的基础上加用槐杞黄颗粒治疗，7 d为1个疗程。比较两组患儿的治疗效果及临床症状体征消失时间、住院时间，并采用ELISA法检测血清中IL-17和IL-23表达的变化。
结果：观察组的治疗总有效率为94.29%(33/35)，显著高于对照组74.29%(26/35)，差异有统计学意义(P<0.05)。观察组临床症状、体征的消失时间及住院时间均显著低于对照组，差异有统计学意义(P<0.05)。治疗后观察组患儿IL-17和IL-23的表达均显著低于对照组，差异有统计学意义(P<0.05)。
结论：槐杞黄颗粒能够显著提高RSV毛细支气管炎患儿的治疗效果，其机制可能与降低IL-17和IL-23的表达有关。

关键词: 毛细支气管炎, 槐杞黄颗粒, IL-17, IL-23, 呼吸道合胞病毒, 儿童

Abstract:
Objective：To observe the clinical effect of Huaiqihuang granule in the treatment of respiratory syncytial virus(RSV) bronchiolitis in children.
Methods：Totally 70 children with RSV bronchiolitis were randomly divided into the observation group(n=35) and the control group(n=35), who received treatment from May 2014 to February 2016. The patients in the control group were treated with inhaling oxygen, relieving cough and asthma, reducing phlegm and other conventional treatment, while patients in the observation group were treated with Huaiqihuang granule on the basis of the treatment for control group for 7 days as a course of treatment. The effect and time for clinical symptoms and signs to disappear and hospitalization time were compared between the two groups, and the changes of IL-17 and IL-23 in serum were detected by ELISA method.
Results：The total effective rate of the observation group was 94.29%(33/35), which was significantly higher than 74.29%(26/35) of the control group, and the difference was statistically significant(P<0.05). The time for clinical symptoms and signs to disappear and hospital stay in the observation group were significantly shorter than those in the control group, the difference being statistically significant(P<0.05). After treatment, the expression of IL-17 and IL-23 in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05).
Conclusion：Huaiqihuang granule can significantly improve the therapeutic effect on RSV bronchiolitis in children, and its mechanism may be related to the decrease of the expression of IL-17 and IL-23.

Key words: Bronchiolitis, Huaiqihuang granule, IL-17, IL-23, Respiratory syncytial virus, Child