关键词: 脓毒血症, 血清脑钠肽, C反应蛋白, 肿瘤坏死因子α, 婴儿, 新生

Abstract:
Objective：To study the relationship of serum BNP level with inflammatory factors and prognosis of neonatal sepsis.
Methods：Fifty cases of neonatal sepsis in our hospital were selected and the level of BNP,CRP,IL-10 and TNF-α was determined with Elias method The change of these levels were observed after 12 h, 24 h and 48 h treatment. The outcome of neonatal sepsis was analyzed based on BNP level ≥150 ng/L and <150 ng/L.
Results：The children in BNP≥150 ng/L group had higher APACHE scores(21.36±2.68) and mortality was 34.5%(10/29),which was higher than the children with BNP<150 ng/L, the difference being statistical(P<0.05).Spearman correlation analysis showed that the BNP was positively correlated with CRP and TNF-α and negative correlation with IL-10(P<0.01). With the extension of treatment, the BNP,CRP and TNF-α levels were significantly decreased and IL-10 increased which had statistical difference compared with before treatment and 12 h and 24 h after treatment(P<0.05).
Conclusion：The patients with neonatal sepsis have obviously high levels of brain natriuretic peptide, which is closely related to the level of inflammatory factors and treatment length. Cardiac insufficiency may exist in these children and promote the disease progress by mediating inflammation.

Key words: Sepsis, Serum brain natriuretic peptide, C-reactive protein, Tumor necrosis factor alpha, Baby,new born