关键词: 支气管肺发育不良, 肺表面活性物质, 肺功能, 儿童

Abstract:
Objective
To analyze the clinical value of early use of pulmonary surfactant(PS) in children with bronchopulmonary dysplasia(BPD).
Methods
From March 2013 to May 2016, 68 children with BPD were admitted to the Neonatal Department of Henan Hongli Hospital. They were randomly divided into the observation group and the control group, each with 34 cases. The control group was treated with conventional mechanical ventilation and oxygen inhalation, and the observation group was treated with PS in addition to the conventional treatment. The oxygen intake time, mechanical ventilation time and pulmonary function were compared between the two groups. The treatment lasted for 2 weeks in both groups.
Results
In the observation group, oxygen time and mechanical ventilation time were significantly shorter than the control group, the difference being statistically significant (P<0.05); the lung function at 1 year and 2 years old was significantly better in observation group than the control group, the difference being statistically significant (P<0.05).
Conclusion
The early application of PS in the treatment of BPD is effective, which can shorten the time of mechanical ventilation, reduce lung injury and improve lung function, and is worthy of promotion.

Key words: Bronchopulmonary dysplasia, Pulmonary surfactant, Lung function, Child