ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (3): 219-221.doi: 10.3969/j.issn.1674-3865.2017.03.011

• 临床研究 • 上一篇    下一篇

雾化吸入普米克令舒联合可必特治疗对哮喘患儿免疫功能的影响

赖华基，林世江，李永华何高锋，饶慧玲   

  1. 512000 广东 韶关，韶关市第一人民医院儿科
  • 出版日期:2017-06-25 发布日期:2017-12-08
  • 通讯作者: 赖华基，E-mail：rizhao2563@163.com
  • 作者简介:赖华基（1979-），男，主治医师。研究方向：小儿呼吸系统疾病的诊治

Effect of aerosol inhalation of pulmicort respules combined with Combivent on immune function in children with asthma

LAI Huaji, LIN Shijiang, LI Yonghua, HE Gaofeng, RAO Huiling   

  1. The First People's Hospital of Shaoguan City,Shaoguan 512000,China
  • Online:2017-06-25 Published:2017-12-08

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摘要：
目的
探讨雾化吸入普米克令舒联合可必特治疗对哮喘患儿免疫功能的影响。
方法
2015年1月至2016年3月韶关市第一人民医院儿科收治住院的轻、中度喘息性疾病患儿120例，随机分为观察组和对照组各60例。对照组雾化吸入普米克令舒治疗，观察组雾化吸入普米克令舒联合可必特治疗。治疗2周后观察两组患儿临床疗效、临床症状体征缓解时间、肺功能［最大用力呼气流量(PEF)、计算PEF测定值占预计值的百分比(PEF%)］及免疫学指标［IgE与外周嗜酸性粒细胞(EOS)］。
结果
观察组总有效率为96.67%（58/60），高于对照组81.67%（49/60），差异有统计学意义（P<0.05）；观察组咳嗽、气喘、肺部哮鸣音消失时间均显著短于对照组，差异有统计学意义（P<0.05）；治疗后两组PEF、PEF%水平均显著升高，且观察组显著高于对照组，差异有统计学意义（P<0.05）；治疗后两组IgE、EOS水平均显著降低，且观察组显著低于对照组，差异有统计学意义（P<0.05）。
结论
雾化吸入普米克令舒联合可必特治疗儿童哮喘疗效确切，能够加快患儿的恢复速度，对改善患儿肺功能、免疫功能等指标具有积极作用，值得临床广泛应用。 

关键词: 哮喘, 雾化吸入, 普米克令舒, 可必特, 免疫功能, 儿童

Abstract:
Objective
To investigate the effect of aerosol inhalation of pulmicort respules combined with Combivent on immune function in children with asthma.
Methods
A total of 120 children with mild to moderate asthmatic diseases treated in Supplementary Department of Shaoguan First People's Hospital from January 2015 to March 2016 were selecetd, and they were divided into observation group and control group by random number table, 60 cases in each group. Control group was given aerosol inhalation of pulmicort respules, while observation group was treated with aerosol inhalation of pulmicort respules combined with Combivent. After a twoweek treatment, the clinical efficacy, remission time of clinical signs, lung function［peak expiratory flow(PEF), PEF%］ and immunological indexes ［immunoglobulin E(IgE) and eosinophil(EOS)］ were compared between the two groups.
Results
The total effective rate of observation group was 96.67%(58/60), which was higher than 81.67%(49/60) of control group(P<0.05). The disappearance time of cough, asthma, wheezing rale in observation group were shorter than those in control group(P<0.05). After treatment, the levels of PEF and PEF% in two groups significantly increased, and observation group was higher than control group(P<0.05). After treatment, the levels of IgE and EOS in two groups significantly decreased, and observation group was lower than control group(P<0.05).
Conclusion
Aerosol inhalation of pulmicort respules combined with Combivent is effective in treatment of children with asthma, and it can accelerate recovery and improve lung function and immune function, which is worthy of wide clinical application.

Key words: Asthma, Aerosol inhalation, Pulmicort respules, Combivent, Immune function, Children