ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (3): 225-227.doi: 10.3969/j.issn.1674-3865.2017.03.013

• 临床研究 • 上一篇    下一篇

氯雷他定联合孟鲁司特钠治疗小儿咳嗽变异性哮喘疗效观察

王瑞丽，李磊，朱崇峰   

  1. 466000 河南 周口，周口市中心医院小儿内科
  • 出版日期:2017-06-25 发布日期:2017-12-08
  • 通讯作者: 王瑞丽，E-mail：598634874@qq.com
  • 作者简介:王瑞丽(1983-)，女，主治医师。研究方向：小儿呼吸系统疾病的诊治

Clinical effect of loratadine combined with montelukast on children with cough variant asthma

WANG Ruili，LI Lei，ZHU Chongfeng   

  1. Department of Pediatric Internal Medicine, Zhoukou Central Hospital, Zhoukou 466000, China
  • Online:2017-06-25 Published:2017-12-08

PDF (PC)

114

摘要：
目的
观察氯雷他定联合孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床疗效。
方法
2015年1月至2016年1月周口市中心医院小儿内科收治住院的咳嗽变异性哮喘患儿80例，随机分为观察组和对照组各40例。对照组给予孟鲁司特钠咀嚼片口服，每次5 mg，每日1次，治疗3个月。观察组在对照组治疗基础上口服氯雷他定片，每日睡前服用，每次5 mg，连续服用2周。停药观察2个月，比较两组患儿的临床症状、体征缓解情况及治疗效果。
结果
观察组治疗总有效率为95.0%(38/40)，显著高于对照组77.5%(31/40)，差异有统计学意义(P<0.05)。观察组咳嗽消失时间、哮喘持续时间及咳痰消失时间均短于对照组，差异有统计学意义(P<0.05)。
结论
氯雷他定联合孟鲁司特钠治疗小儿咳嗽变异性哮喘疗效明显。

关键词: 咳嗽变异性哮喘, 氯雷他定, 孟鲁司特钠, 儿童

Abstract:
Objective
To study the clinical effect of loratadine combined with montelukast on children with cough variant asthma.
Methods
From Jan. 2015 to Jan. 2016, a total of 80 children with cough variant asthma hospitalized  in our hospital for treatment were taken as the clinical research objects, and they were randomly divided into control group(40 cases）and treatment group(40 cases）. Both groups were treated with montelukast chewable tablets,5 mg per time, once a day for 3 months; besides, the treatment group was additionally given loratadine 5 mg before bedtime for continuous 2 months. The clinical efficacy and improvement of physical signs and symptoms in the two groups were compared after stopping the treatment for 2 months.
Results
The total effective rate in the treatment group was 95.0%, which was significantly higher than that in the control group(77.5%,P<0.05）;the disappearance time of cough and expectoration, and asthma duration in the treatment group were all shorter than those in the control group（P<0.05）.
Conclusion
Loratadine combined with montelukast has significant effect in the treatment of children with cough variant asthma.

Key words: Cough variant asthma, Loratadine, Montelukast, Children