关键词: 中枢神经系统感染, C反应蛋白, 血清, 脑脊液, 儿童

Abstract:
Objective
To study and analyze the clinical value of C-reactive protein detection in children with central nervous infection.
Methods
A total of 88 children with central nervous infection were included in the study, who were hospitalized in Xinyi People's Hospital from Jan. 2013 to Jan. 2016; there were 38 cases of purulent meningitis and 50 cases of viral meningitis. The control group consisted of 75 healthy children in our hospital at the same period. Laboratory tests were performed in these 3 groups of children, and compare the level of C-reactive protein in serum and cerebrospinal fluid.
Results
The level of C-reactive protein in serum and cerebrospinal fluid in the purulent group and the viral group was higher than that in the control group(P<0.01), and the level in purulent group was higher than that in the viral group, with statistical difference(P<0.01). The serum and cerebrospinal fluid level in both purulent and viral groups at recovery stage was lower than that at acute stage, and the level decrease in viral group was greater than that in purulent stage at recovery stage; there was statistical difference(P<0.01).
Conclusion
The detection of C-reactive protein in children with central nervous infection is beneficial to the differentiated diagnosis of purulent meningitis and viral meningitis. Because it's easier to obtain serum samples, the level of serum C-reactive protein alone can be used as an important biochemical testing indicator in children with central nervous infectious disease.

Key words: Central nervous infection, C-reactive protein, Serum, Cerebrospinal fluid, Child