ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (3): 249-251.doi: 10.3969/j.issn.1674-3865.2017.03.021

• 临床研究 • 上一篇    下一篇

降钙素原检测在鉴别小儿细菌性和病毒性脑膜炎的意义

张晓俐，严海燕，宋丽芳   

  1. 450000 郑州，郑州市儿童医院急诊科(张晓俐)，消化内科(严海燕)，神经内科(宋丽芳)
  • 出版日期:2017-06-25 发布日期:2017-12-08
  • 通讯作者: 张晓俐，E-mail：zhangxiaolisy@yeah.net
  • 作者简介:张晓俐(1968-)，女，副主任医师。研究方向：儿童急诊相关疾病的诊治

Significance of procalcitonin in the identification of bacterial and viral meningitis in children

ZHANG Xiaoli，YAN Haiyan，SONG Lifang   

  1. Department of Emergency, Zhengzhou Children's Hospital, Zhengzhou 450000，China
  • Online:2017-06-25 Published:2017-12-08

PDF (PC)

162

摘要：
目的
分析降钙素原(PCT)在鉴别小儿细菌性脑膜炎与病毒性脑膜炎的意义。
方法
2013年1月至2015年12月郑州市儿童医院神经内科收治的脑膜炎患儿80例，经临床与实验室确诊，细菌性脑膜炎38例，病毒性脑膜炎42例。使用胶体金免疫层析法检测两组患儿的PCT水平，采用免疫增强比浊法检测血常规白细胞、C反应蛋白(CRP)、脑脊液白细胞水平。
结果
细菌性脑膜炎组患儿血常规白细胞为(15.4±5.4)×109/L，血清CRP为(52.6±27.2)mg/L，脑脊液白细胞为(392.1±42.8)×106/L，均高于病毒性脑膜炎组(8.4±3.6)×109/L、(20.5±10.4)mg/L、(33.2±20.9)×106/L，差异有统计学意义(P<0.05)。细菌性脑膜炎组患儿的血清PCT为(13.2±5.6)μg/L，脑脊液PCT为(0.9±0.4)μg/L，均高于病毒性脑膜炎组(0.7±0.3)μg/L、(0.2±0.1)μg/L，差异有统计学意义(P<0.05)。
结论
PCT作为一种敏感而特异的血清标志物，能够对早期患儿细菌性脑膜炎与病毒性脑膜炎进行鉴别，检测操作简单，安全性高，具有积极的临床意义。

关键词: 细菌性脑膜炎, 病毒性脑膜炎, 降钙素原, 鉴别意义, 儿童

Abstract:
Objective
To analyze the significance of procalcitonin(PCT) in the differential diagnosis of bacterial meningitis and viral meningitis in children.
Methods
Eighty children with meningitis who were treated in Zhengzhou Children's Hospital from Jan. 2013 to Dec. 2015 were included in the study. It was clinically and laboratorily confirmed that there were 38 cases of bacterial meningitis and 42 cases of viral meningitis. The PCT levels were measured by colloidal gold immunochromatography. The levels of leukocytes, Creactive protein(CRP) and cerebrospinal fluid(WBC) were measured by immunoturbidimetry.
Results
In the bacterial meningitis group, the blood leukocytes were (15.4±5.4)×109/ L, serum CRP was (52.6±27.2) mg/L, and cerebrospinal fluid leukocytes were (392.1±42.8)×106/L; in viral meningitis group they were（8.4±3.6）×109/L,（20.5±10.4）mg/L and （33.2±20.9）×106/L, the difference being statistically significant(P<0.05). The serum PCT of the patients with bacterial meningitis was (13.2±5.6) μg/L and the cerebrospinal fluid PCT was (0.9±0.4) μg/L, while in viral meningitis group they were （0.7±0.3）μg/L and （0.2±0.1）μg/L, the difference being  statistically significant(P<0.05).
Conclusion
PCT, as a sensitive and specific serum marker, can be used for the identification of bacterial meningitis and viral meningitis in children. It is simple, safe and has a positive clinical significance.

Key words: Bacterial meningitis, Viral meningitis, Procalcitonin, Differential significance, Children