ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (3): 252-255.doi: 10.3969/j.issn.1674-3865.2017.03.022

• 临床研究 • 上一篇    下一篇

畅迪试剂脱敏治疗小儿过敏性鼻炎的临床疗效及对嗜酸性粒细胞、嗜酸性粒细胞阳离子蛋白水平的影响

陈毛毛   

  1. 523320 广东 东莞，东莞市第八人民医院耳鼻咽喉科
  • 出版日期:2017-06-25 发布日期:2017-12-08
  • 作者简介:陈毛毛（1980-），男，主治医师。研究方向：小儿耳鼻咽喉疾病的诊治，E-mail：chenmaomao02@sina.com

Clinical effect of Changdi reagent desensitization on children with allergic rhinitis and its effect on eosinophils and eosinophil cationic protein

CHEN Maomao   

  1. The Eighth People's Hospital of Dongguan, Dongguan 523320, China
  • Online:2017-06-25 Published:2017-12-08

PDF (PC)

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摘要：
目的
探究畅迪试剂脱敏疗法对小儿过敏性鼻炎的治疗效果和对患儿嗜酸性粒细胞(EOS)、嗜酸性粒细胞阳离子蛋白（ECP）水平的影响。
方法
2015年8月至2016年6月东莞市第八人民医院耳鼻咽喉科门诊收治过敏性鼻炎患儿108例，随机分为观察组和对照组各54例。观察组患儿给予畅迪试剂脱敏治疗，对照组患儿给予常规治疗，比较两组患儿临床疗效、治疗后症状体征指标得分和EOS、ECP水平变化。
结果
观察组总有效率为96.30%（52/54），显著高于对照组81.48%（44/54），差异有统计学意义（P<0.05）。观察组治疗后症状体征评分均低于对照组，差异有统计学意义（P<0.05）。治疗后观察组患儿鼻灌洗液中EOS阳性率为75.93%（41/54），显著低于对照组92.59%（50/54），差异有统计学意义（P<0.05）。治疗后观察组患儿鼻灌洗液中ECP含量显著低于对照组，差异有统计学意义（P<0.05）。
结果
畅迪试剂脱敏疗法对提高小儿过敏性鼻炎的治疗效果具有积极作用，能够明显降低患儿EOS、ECP水平，减少患儿过敏性鼻炎的发生次数，降低对患儿的影响，具有临床推广价值。

关键词: 过敏性鼻炎, 畅迪试剂脱敏疗法, 嗜酸性粒细胞, 嗜酸性粒细胞阳离子蛋白, 儿童

Abstract:
Objective
To investigate the effect of Changdi reagent desensitization therapy on children with allergic rhinitis and its effect on eosinophil(EOS) and eosinophil cationic protein(ECP) in children.
Methods
From August 2015 to June 2016, 108 children with allergic rhinitis were admitted to the Department of Otorhinolaryngology for treatment, and they were divided into observation group and control group according to the random number table method, 54 cases in each group. The children in the observation group were given desensitization therapy, and the control group was given routine treatment. The clinical curative effect of the two groups was compared. The scores of symptoms and signs and the change of EOS and ECP after treatment was also compared.
Results
The total effective rate was 96.30%(52/54) in the observation group, which was significantly higher than that in the control group(81.48%, 44/54), the difference being statistically significant(P<0.05). The scores of the symptoms and signs in the observation group were lower than those in the control group(P<0.05). The positive rate of EOS in nasal irrigation was 75.93%(41/54) in the observation group, which was significantly lower than that in the control group(92.59%, 50/54), the difference being statistically significant(P<0.05). The content of ECP in the nasal irrigation solution of the observation group was significantly lower than that of the control group(P<0.05).
Conclusion
The desensitization therapy of Changdi reagent has a positive effect in improving the therapeutic effect on allergic rhinitis in children, which can significantly reduce the level of EOS and ECP in these children. It can also decrease the incidence of allergic rhinitis and reduce the impact on these children, which is worth promoting clinically.

Key words: Allergic rhinitis, Changdi reagent desensitization therapy, Eosinophils, Eosinophil cationic protein, Children