关键词: 侵袭性真菌感染, 临床特征, 病原菌, 儿童

Abstract:
Objective
To analyze the clinical features and pathogens of invasive fungal infection in children.
Methods
A total of 150 children with invasive fungal infection were treated in the Infection Department of Hunan Children's Hospital from Mar. 2015 to Mar. 2016. They were included in the study and divided into 3 groups: neonate group(0 to 28 d), infant group(>28 d to 3 years) and older child group(>3 to 14 years), 50 in each group. The risk factors, pathogen distribution and infection site were analyzed.
Results
The analysis of the risk factors of invasive fungal infection in children showed that parenteral nutrition venous catheterization, and antibiotic use for over 7 days were the main risk factors in neonates, parenteral nutrition and mechanical ventilation were mainly in infants, and antibiotic use for over 7 days, combined use of two antibiotics and chemotherapy for tumors in the older children, the difference among them being statistically significant(P<0.05). The pathogen distribution of invasive fungal infection was as follows: Candida albicans, Candida glabrata and Candida parapsilosis were the main pathogenic bacteria in neonates, Candida albicans and Candida glabrata were mainly in infants, and Candida albicans in older children, and there was statistically significant difference among the 3 groups(P<0.05). Lung is the common infection site in neonate group(66%),lung(46%) and intestine(40%) in infant group, lung(68%) in older child group, although other sites of infection were also seen in older children, the difference among them being significant(P<0.05).
Conclusion
The main pathogen of invasive fungal infection in children are Candida albicans, Candida glabrata and Candida parapsilosis. The clinical manifestations are mainly pulmonary and intestinal infection. The pathogen types and infection factors should be taken into account during the treatment.

Key words: Invasive fungal infections, Clinical features, Pathogens, Children