ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (6): 510-512.doi: 10.3969/j.issn.1674-3865.2017.06.016

• 临床研究 • 上一篇    下一篇

磷酸肌酸与果糖二磷酸钠治疗小儿心肌炎疗效观察

石天霄   

  1. 467000 河南 平顶山，平顶山市妇幼保健院新生儿科
  • 出版日期:2017-12-25 发布日期:2018-11-19
  • 作者简介:石天霄（1972-），女，副主任医师。研究方向：小儿心血管系统疾病的诊治，E-mail：15026581827@qq.com

Clinical effect of phosphocreatine and fructose diphosphate for children with myocarditis

SHI Tianxiao   

  1. Pingdingshan Maternal and Child Health Care Hospital，Pingdingshan 467000，China
  • Online:2017-12-25 Published:2018-11-19

PDF (PC)

76

摘要：
目的
探究果糖二磷酸钠与磷酸肌酸治疗小儿心肌炎的疗效。
方法
选取2015年2月至2016年4月平顶山市妇幼保健院新生儿科收治住院的心肌炎患儿82例，随机分为观察组与对照组各41例。观察组给予果糖二磷酸钠治疗，对照组给予磷酸肌酸治疗。7～10 d为1个疗程。观察两组治疗效果及心脏肌钙蛋白I（cTnI）、肌钙蛋白T（cTnT）、乳酸脱氢酶1（LDH-1）以及肌酸激酶同工酶（CK-MB）水平。
结果
观察组治疗总有效率为92.68%（38/41），显著高于对照组65.85%（27/41），差异有统计学意义（P<0.05）。治疗前两组患儿cTnI、cTnT、LDH-1以及CK-MB水平比较差异无统计学意义（P>0.05）；治疗后观察组cTnI、cTnT以及LDH-1水平显著低于对照组，差异有统计学意义（P<0.05）；治疗后两组CK-MB水平比较差异无统计学意义（P>0.05）。
结论
相较于磷酸肌酸，果糖二磷酸钠对心肌炎患儿具有更好的治疗效果，明显改善患儿心肌功能，减轻炎症症状，值得临床应用及推广。

关键词: 心肌炎, 磷酸肌酸, 果糖二磷酸钠, 儿童

Abstract:
Objective
To study the clinical effect of phosphocreatine and fructose diphosphate for children with myocarditis.
Methods
A total of 82 children with Myocarditis treated from February 2015 to April 2016 in our hospital were selected.The subjects were randomly divided into two groups,41 cases in each group.The observation group took fructose diphosphate;the control group took phosphocreatine;the treatment lasted for 7-10 d as a course.The clinical effect of the two groups was compared,and level of cTnI,cTnT,LDHI-1 and CK-MB was also observed.
Results
The total effective rate of observation group (92.68%,38/41) was higher than that of control group(65.85%,27/41)(P<0.05).The level of cTnI,cTnT and LDH-1 had no significant difference before treatment between the two groups.After treatment,these levels of observation group were significantly lower than those of control group (P<0.05),but CK-MB level was not statistically different (P>0.05).
Conclusion
Compared with phosphocreatine,fructose diphosphate has a better effect on children with myocarditis,and can improve the children's cardiac function and alleviate inflammation,which is worthy of clinical application.

Key words: Myocarditis, Phosphocreatine, Fructose diphosphate, Child