ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2017, Vol. 9 ›› Issue (6): 527-529.doi: 10.3969/j.issn.1674-3865.2017.06.022

• 临床研究 • 上一篇    下一篇

阿奇霉素联合激素治疗重症/难治性肺炎支原体肺炎疗效观察

唐卫珍，徐红梅，阚惠娟，李世芹   

  1. 215002 江苏 苏州，苏州市立医院儿科
  • 出版日期:2017-12-25 发布日期:2018-11-19
  • 通讯作者: 唐卫珍，E-mail：szhangy7102@163.com
  • 作者简介:唐卫珍（1971-），女，副主任医师。研究方向：儿童呼吸系统、心血管系统疾病的诊治

Clinical efficacy of Azithromycin combined with glucocorticoid in the treatment of severe/refractory Mycoplasma pneumoniae pneumonia

TANG Weizhen，XU Hongmei，KAN Huijuan，LI Shiqin   

  1. Department of Pediatrics，Suzhou Municipal Hospital，Suzhou 215002，China
  • Online:2017-12-25 Published:2018-11-19

PDF (PC)

94

摘要：
目的
探讨阿奇霉素联合激素治疗重症/难治性肺炎支原体肺炎的临床效果。
方法
选择2013年1月至2016年12月苏州市立医院儿科收治住院的重症/难治性肺炎支原体肺炎患儿102例作为研究对象，随机分为对照组和观察组各51例。对照组给予阿奇霉素静脉滴注治疗，7 d为1个疗程，治疗4个疗程；观察组在对照组治疗基础上给予静脉滴注甲泼尼龙琥珀酸钠，治疗5 d。两组临床疗效、患儿临床症状体征消失时间、住院时间及不良反应发生率。
结果
观察组总有效率为96.1%（49/51），显著高于对照,76.5%（39/51），差异有统计学意义（P<0.05）。观察组患儿退热时间、啰音消失时间、咳嗽好转时间以及平均住院时间显著少于对照组，差异有统计学意义（P＜0.05）。观察组治疗7 d后C反应蛋白水平显著低于对照组，差异有统计学意义(P＜0.05)。两组不良反应发生率比较差异无统计学意义（P>0.05）。
结论
阿奇霉素联合激素可改善患儿的临床症状体征，缩短住院时间，提高治疗效果。

关键词: 肺炎, 支原体, 阿奇霉素, 儿童

Abstract:
Objective
To investigate the effect of Azithromycin combined with glucocorticoid in children with severe/refractory Mycoplasma pneumonia.
Methods
A total of 102 children with severe/refractory Mycoplasma pneumonia treated in our hospital were selected as the research object，and were divided into the control group and the research group randomly，51 cases in each group. The control group was treated with Azithromycin intravenous drip，and the research group was treated with Azithromycin and methylprednisolone sodium succinate. The clinical symptoms and signs， the disappearance time， the effective and the adverse rates of the two groups were observed during the treatment.
Results
The symptoms disappearance time，hospitalization time and the incidence of adverse reactions of the study group were significantly lower than those in the control group(P<0.05). The total effective rate of the study group(96.1%) was significantly higher than that of the control group(76.5%，P<0.05).
Conclusion
Azithromycin combined with glucocorticoid can improve the clinical symptoms and signs of patients with Mycoplasma pneumonia， shorten hospital stay，improve the curative effect and reduce the incidence of adverse reactions.

Key words: Pneumonia, Mycoplasma, Azithromycin, Children