ISSN 1674-3865  CN 21-1569/R
主管：国家卫生健康委员会
主办：中国医师协会
　　　辽宁省基础医学研究所
　　　辽宁中医药大学附属医院
中国中西医结合儿科学

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 93-95.doi: 10.3969/j.issn.1674-3865.2018.02.001

• 临床论著 •    下一篇

糖皮质激素联合丙种球蛋白对小儿肺炎临床症状和炎症指标的影响

薛飞，汪受传   

  1. 264000山东 烟台，烟台市中医医院儿科（薛飞）；210029 南京，江苏省中医院儿科（汪受传）
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 通讯作者: 薛飞，E-mail：xf3439@163.com
  • 作者简介:薛飞（1982-），男，南京中医药大学2016级博士研究生在读，主治医师。研究方向：中西医结合治疗儿科相关疾病
  • 基金资助:
    国家自然科学基金项目（81373688）

Effects of glucocorticoid combined with gamma globulin on clinical symptoms and inflammatory indexes in children with pneumonia

XUE Fei，WANG Shouchuan   

  1. Yantai Traditional Chinese Medicine Hospital，Yantai 264000，China
  • Online:2018-04-25 Published:2018-11-19

PDF (PC)

86

摘要：
目的
探讨糖皮质激素联合丙种球蛋白对小儿肺炎临床症状和炎症指标的影响。
方法
选取2015年4月至2017年4月烟台市中医医院儿科收治住院的肺炎患儿80例，随机分为联合治疗组和单独治疗组各40例。两组患儿均给予常规支持治疗。单独治疗组静脉注射丙种球蛋白；联合治疗组静脉滴注甲泼尼龙注射液和强的松注射液，同时给予患儿静脉滴注丙种球蛋白。3～5 d为1个疗程。观察两组临床疗效、患儿症状体征消失时间及住院时间、患儿血清炎症指标水平。
结果
联合治疗组患儿治疗总有效率为92.5%（37/40），显著高于单独治疗组70.0%（28/40），差异有统计学意义（P<0.05）。联合治疗组退热时间、止咳时间、啰音消失时间、阴影吸收时间、住院时间均显著短于单独治疗组，差异有统计学意义（P<0.05）。联合治疗组血清白细胞计数、C反应蛋白、降钙素原水平均显著低于单独治疗组，差异有统计学意义（P<0.05）。
结论
糖皮质激素联合丙种球蛋白较单独丙种球蛋白治疗小儿肺炎更能有效改善患儿的临床症状降低患儿的血清炎症指标水平。

关键词: 肺炎, 糖皮质激素, 丙种球蛋白, 临床症状, 炎症指标, 儿童

Abstract:
objective
To investigate the effect of glucocorticoid combined with gamma globulin on clinical symptoms and inflammatory markers in children with pneumonia.
Methods
A total of 80 cases of pediatric pneumonia in our hospital from April 2015 to April 2017 were selected, and according to the treatment methods, these patients were divided into glucocorticoid plus gamma globulin treatment group(combined treatment group,n=40) and single gamma globulin treatment group (single treatment group,n=40). Both groups were given conventional supporting treatment. The single treatment group received intravenous injection of gamma globulin. The combined treatment group received intravenous dripping of methylprednisolone injection and prednisone injection in addition to gamma globulin.The treatment lasted for 3 to 5 day as a course. Observe the clinical effect, the time for symptoms and signs to disappear, length of hospital stay and the serum level of inflammatory markers in the two groups.
Results
The total effective rate of combined treatment group was 92.5%(37/40), significantly higher than that of the single treatment group(70.0%, 28/40)(P<0.05).The time for fever, cough and rales to disappear and the time of shadow absorption as well as the length of hospital stay in the combined treatment group were significantly shorter than the single treatment group(P<0.05). The level of WBC count, CRP and PCT was significantly lower in the combined treatment group than in the single treatment group(P<0.05).
Conclusion
Compared with gamma globulin alone, glucocorticoid combined with gamma globulin can effectively improve the clinical symptoms of children with pneumonia, and reduce the level of serum inflammatory markers in children.

Key words: Pneumonia, Glucocorticoid, Gamma globulin, Clinical symptoms, Inflammatory markers, Child