ISSN 1674-3865  CN 21-1569/R
主管:国家卫生健康委员会
主办:中国医师协会
   辽宁省基础医学研究所
   辽宁中医药大学附属医院

中国中西医结合儿科学 ›› 2018, Vol. 10 ›› Issue (2): 96-98.doi: 10.3969/j.issn.1674-3865.2018.02.002

• 临床论著 • 上一篇    下一篇

毛细支气管炎患儿血Th1/Th2相关细胞因子水平的研究

孙同英,崔振泽,黄燕,徐超   

  1. 116000 辽宁 大连,大连医科大学2014级儿科专业研究生(孙同英);大连市儿童医院呼吸科(崔振泽,黄燕,徐超)
  • 出版日期:2018-04-25 发布日期:2018-11-19
  • 通讯作者: 黄燕,E-mail:13304280868@126.com
  • 作者简介:孙同英(1989-),女,大连医科大学2014级硕士研究生在读。研究方向:小儿呼吸系统疾病的研究 通讯作者:黄燕,E-mail:13304280868@126.com
  • 基金资助:
    国家自然科学基金项目(81473726);辽宁省自然科学基金项目(2014020173)

Study on Th1/Th2-related cytokines in children with bronchiolitis

SUN Tongying,CUI Zhenze,HUANG Yan,XU Chao   

  1. Dalian Medical University, Dalian 116000,China
  • Online:2018-04-25 Published:2018-11-19

摘要:
目的
从Th1/Th2平衡角度探讨毛细支气管炎住院患儿血清中免疫细胞因子水平的变化,阐明毛细支气管炎的发病机制,为预防其日后发展为哮喘提供理论依据。
方法
选择2016年9月至2017年2月大连市儿童医院呼吸科收治住院的毛细支气管炎患儿30例为观察组,同期选择本院健康体检儿童30例为对照组。运用酶联免疫吸附法(Elisa)对两组患儿血清γ干扰素(IFN-γ)、白细胞介素(IL-4、IL-10、IL-13、IL-33、IL-17)水平进行检测。
结果
与对照组比较,观察组IL-4、IL-10、IL-13、IL-33、IL-17水平升高,差异有统计学意义(P<0.05)。
结论
小儿毛细支气管炎发病与相关免疫细胞因子水平的变化密切相关,机体处于Th1/Th2免疫失衡状态。

关键词: 毛细支气管炎, Th1, Th2, 免疫细胞因子, 儿童

Abstract:
objective
To study the changes of serum levels of immune cytokines in children with bronchiolitis based on Th1/Th2 balance in order to clarify the pathogenesis of bronchiolitis and provide a theoretical basis for preventing bronchiolitis from developing asthma in the future.
Methods
From September 2016 to February 2017, 30 children with bronchiolitis admitted to the Department of Respiratory Diseases of Children's Hospital of Dalian were treated and were chosen as observation groups. At the same time, the healthy children of the same age were selected as the control group. Use Elisa method to detect the changes of immune cytokines(IFN-γ,IL-4,IL-10,IL-13,IL-33 and IL-17) in serum of both groups.
Results
Compared with the control group,the level of IL-4,IL-10,IL-13,IL-33 and IL-17 in the observation group was significantly higher than that in the control group(P<0.05).
Conclusion:The morbidity of bronchiolitis in children is closely related to changes of the level of cytokines,and the body is in Th1/Th2-related immune imbalance.

Key words: Bronchiolitis, Th1/Th2, Immune cytokines, Children